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Aptamer-Based Antibacterial and Antiviral Therapy against Infectious Diseases.
Chen, Xiao-Fei; Zhao, Xin; Yang, Zifeng.
  • Chen XF; Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center, Guangzhou), Guangzhou 510070, PR China.
  • Zhao X; Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, Institute of Analysis, Guangdong Academy of Sciences (China National Analytical Center, Guangzhou), Guangzhou 510070, PR China.
  • Yang Z; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, PR China.
J Med Chem ; 64(24): 17601-17626, 2021 12 23.
Article in English | MEDLINE | ID: covidwho-2084518
ABSTRACT
Nucleic acid aptamers are single-stranded DNA or RNA molecules selected in vitro that can bind to a broad range of targets with high affinity and specificity. As promising alternatives to conventional anti-infective agents, aptamers have gradually revealed their potential in the combat against infectious diseases. This article provides an overview on the state-of-art of aptamer-based antibacterial and antiviral therapeutic strategies. Diverse aptamers targeting pathogen-related components or whole pathogenic cells are summarized according to the species of microorganisms. These aptamers exhibited remarkable in vitro and/or in vivo inhibitory effect for pathogenic invasion, enzymatic activities, or viral replication, even for some highly drug-resistant strains and biofilms. Aptamer-mediated drug delivery and controlled drug release strategies are also included herein. Critical technical barriers of therapeutic aptamers are briefly discussed, followed by some future perspectives for their implementation into clinical utility.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Communicable Diseases / Aptamers, Nucleotide / Anti-Bacterial Agents Type of study: Experimental Studies / Prognostic study Limits: Animals / Humans Language: English Journal: J Med Chem Journal subject: Chemistry Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Communicable Diseases / Aptamers, Nucleotide / Anti-Bacterial Agents Type of study: Experimental Studies / Prognostic study Limits: Animals / Humans Language: English Journal: J Med Chem Journal subject: Chemistry Year: 2021 Document Type: Article