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IL-13 determines specific IgE responses and SARS-CoV-2 immunity after mild COVID-19 and novel mRNA vaccination.
Meltendorf, Stefan; Vogel, Katrin; Thurm, Christoph; Prätsch, Florian; Reinhold, Annegret; Färber, Jacqueline; Heuft, Hans-Gert; Kaasch, Achim J; Hachenberg, Thomas; Weinzierl, Stefan; Schraven, Burkhart; Reinhold, Dirk; Brunner-Weinzierl, Monika C; Lingel, Holger.
  • Meltendorf S; Department of Experimental Pediatrics, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Vogel K; Department of Experimental Pediatrics, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Thurm C; Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Prätsch F; Department of Anesthesiology and Intensive Care Medicine, University Hospital Magdeburg, Magdeburg, Germany.
  • Reinhold A; Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Färber J; Institute of Medical Microbiology and Hospital Hygiene, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Heuft HG; Department of Transfusion Medicine and Immunohematology, University Hospital Magdeburg, Magdeburg, Germany.
  • Kaasch AJ; Institute of Medical Microbiology and Hospital Hygiene, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Hachenberg T; Department of Anesthesiology and Intensive Care Medicine, University Hospital Magdeburg, Magdeburg, Germany.
  • Weinzierl S; Audio-Communication Group, Technical University Berlin, Berlin, Germany.
  • Schraven B; Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Reinhold D; Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Brunner-Weinzierl MC; Department of Experimental Pediatrics, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
  • Lingel H; Department of Experimental Pediatrics, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Eur J Immunol ; 2022 Oct 22.
Article in English | MEDLINE | ID: covidwho-2085026
ABSTRACT
After recovery, mild and severe COVID-19 diseases are associated with long-term effects on the host immune system, such as prolonged T-cell activation or accumulation of autoantibodies. In this study, we show that mild SARS-CoV-2 infections, but not SARS-CoV-2 spike mRNA vaccinations, cause durable atopic risk factors such as a systemic Th2- and Th17-type environment as well as activation of B cells responsive of IgE against aeroallergens from house dust mite and mold. At an average of 100 days post mild SARS-CoV-2 infections, anti-mold responses were associated with low IL-13 levels and increased pro-inflammatory IL-6 titers. Acutely severely ill COVID-19 patients instead showed no evidence of atopic reactions. Considering convalescents of mild COVID-19 courses and mRNA-vaccinated individuals together, IL-13 was the predominant significantly upregulated factor, likely shaping SARS-CoV-2 immunity. Application of multiple regression analysis revealed that the IL-13 levels of both groups were determined by the Th17-type cytokines IL-17A and IL-22. Taken together, these results implicate a critical role for IL-13 in the aftermath of SARS-CoV-2 mild infections and mRNA vaccinations, conferring protection against airway directed, atopic side reactions that occur in mildly experienced COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Eji.202249951

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Eji.202249951