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Association between COVID-19 vaccination status, time elapsed since the last vaccine dose, morbidity, and absenteeism among healthcare personnel: A prospective, multicenter study.
Maltezou, Helena C; Gamaletsou, Maria N; Koukou, Dimitra-Maria; Giannouchos, Theodoros V; Sourri, Flora; Syrimi, Natalia; Karapanou, Amalia; Lemonakis, Nikolaos; Peskelidou, Emmanuela; Papanastasiou, Konstantina; Panagopoulos, Periklis; Souliotis, Kyriakos; Lourida, Athanasia; Hatzigeorgiou, Dimitrios; Sipsas, Nikolaos V.
  • Maltezou HC; Directorate of Research, Studies and Documentation, National Public Health Organization, Athens, Greece. Electronic address: maltezou.helena@gmail.com.
  • Gamaletsou MN; Pathophysiology Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Koukou DM; First Department of Pediatrics, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.
  • Giannouchos TV; Department of Health Services Policy and Management, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States.
  • Sourri F; Department of Infection Control, 251 Hellenic Air Force General Hospital, Athens, Greece.
  • Syrimi N; Department of Infection Control, 251 Hellenic Air Force General Hospital, Athens, Greece; Paediatric Department, 251 Air Force General Hospital, Athens, Greece.
  • Karapanou A; Infection Control Committee, Laiko General Hospital, Athens, Greece.
  • Lemonakis N; Infection Control Committee, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
  • Peskelidou E; COVID-19 Intensive Care Unit, 424 General Military Hospital of Thessaloniki, Thessaloniki, Greece.
  • Papanastasiou K; Operating Rooms, 424 General Military Hospital of Thessaloniki, Thessaloniki, Greece.
  • Panagopoulos P; Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
  • Souliotis K; Faculty of Social and Political Sciences, University of Peloponnese, Corinth, Greece; Health Policy Institute, Athens, Greece.
  • Lourida A; Infection Control Committee, Aghia Sofia Children's Hospital, Athens, Greece.
  • Hatzigeorgiou D; Medical Directorate, Hellenic National Defence General Staff, Athens, Greece.
  • Sipsas NV; Pathophysiology Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Vaccine ; 40(52): 7660-7666, 2022 Dec 12.
Article in English | MEDLINE | ID: covidwho-2086815
ABSTRACT

AIM:

We assessed the impact of COVID-19 vaccination status and time elapsed since the last vaccine dose on morbidity and absenteeism among healthcare personnel (HCP) in the context of a mandatory vaccination policy.

METHODS:

We followed 7592 HCP from November 15, 2021 through April 17, 2022. Full COVID-19 vaccination was defined as a primary vaccination series plus a booster dose at least six months later.

RESULTS:

There were 6496 (85.6 %) fully vaccinated, 953 (12.5 %) not fully vaccinated, and 143 (1.9 %) unvaccinated HCP. A total of 2182 absenteeism episodes occurred. Of 2088 absenteeism episodes among vaccinated HCP with known vaccination status, 1971 (94.4 %) concerned fully vaccinated and 117 (5.6 %) not fully vaccinated. Fully vaccinated HCP had 1.6 fewer days of absence compared to those not fully vaccinated (8.1 versus 9.7; p-value < 0.001). Multivariable regression analyses showed that full vaccination was associated with shorter absenteeism compared to not full vaccination (OR 0.56; 95 % CI 0.36-0.87; p-value = 0.01). Compared to a history of ≤ 17.1 weeks since the last dose, a history of > 17.1 weeks since the last dose was associated with longer absenteeism (OR 1.22, 95 % CI1.02-1.46; p-value = 0.026) and increased risk for febrile episode (OR 1.33; 95 % CI 1.09-1.63; p-value = 0.004), influenza-like illness (OR 1.53, 95 % CI 1.02-2.30; p-value = 0.038), and COVID-19 (OR 1.72; 95 % CI 1.24-2.39; p-value = 0.001).

CONCLUSIONS:

The COVID-19 pandemic continues to impose a considerable impact on HCP. The administration of a vaccine dose in less than four months before significantly protected against COVID-19 and absenteeism duration, irrespective of COVID-19 vaccination status. Defining the optimal timing of boosters is imperative.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Vaccine Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Vaccine Year: 2022 Document Type: Article