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Cardiopulmonary work up of patients with and without fatigue 6 months after COVID-19.
Thiele, Kirsten; Balfanz, Paul; Müller, Tobias; Hartmann, Bojan; Spiesshoefer, Jens; Grebe, Julian; Müller-Wieland, Dirk; Marx, Nikolaus; Dreher, Michael; Daher, Ayham.
  • Thiele K; Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH, 52074, Aachen, Germany.
  • Balfanz P; Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH, 52074, Aachen, Germany.
  • Müller T; Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, 52074, Aachen, Germany.
  • Hartmann B; Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH, 52074, Aachen, Germany.
  • Spiesshoefer J; Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, 52074, Aachen, Germany.
  • Grebe J; Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH, 52074, Aachen, Germany.
  • Müller-Wieland D; Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH, 52074, Aachen, Germany.
  • Marx N; Department of Cardiology, Angiology and Intensive Care Medicine, University Hospital RWTH, 52074, Aachen, Germany.
  • Dreher M; Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, 52074, Aachen, Germany.
  • Daher A; Department of Pneumology and Intensive Care Medicine, University Hospital RWTH, 52074, Aachen, Germany. adaher@ukaachen.de.
Sci Rep ; 12(1): 18038, 2022 Oct 27.
Article in English | MEDLINE | ID: covidwho-2087313
ABSTRACT
The pathogenesis of long-Covid symptoms remains incompletely understood. Therefore, we aimed to determine cardiopulmonary limitations 6 months after surviving COVID-19 using pulmonary function tests, echocardiographic studies to the point of analysis of global-longitudinal-strain (GLS), which describes the cycling myocardium deformation and provides better data on left ventricular (LV) dysfunction than LV ejection fraction (LVEF), and validated questionnaires. Overall, 60 consecutive hospitalized patients were included (61 ± 2 years, 40% treated in the ICU). At follow-up (194 ± 3 days after discharge), fatigue was the most prevalent symptom (28%). Patients with fatigue were more symptomatic overall and characterized by worse quality of life (QoL) scores compared to patients without fatigue (all p < 0.05), mainly due to limited mobility and high symptom burden. While PFT variables and LVEF were normal in the vast majority of patients (LVEF = 52% (45-52%)), GLS was significantly reduced (- 15% (- 18 to - 14%)). However, GLS values were not different between patients with and without fatigue. In conclusion, fatigue was the most prevalent long-Covid symptom in our cohort, which was associated with worse QoL mainly due to limited mobility and the high burden of concomitant symptoms. Patients showed a subtle myocardial dysfunction 6 months after surviving COVID-19, but this did not relate to the presence of fatigue.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ventricular Dysfunction, Left / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-22876-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ventricular Dysfunction, Left / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-22876-9