Low Prevalence of Interferon-α Autoantibodies in People Experiencing Long COVID Symptoms.
J Infect Dis
; 2022 Sep 12.
Article
in English
| MEDLINE | ID: covidwho-2244144
ABSTRACT
Interferon (IFN)-specific autoantibodies have been implicated in severe COVID-19 and have been proposed as a potential driver of the persistent symptoms characterizing Long COVID, a type of post-acute sequelae of SARS-CoV-2 infection (PASC). We report than only two of 215 SARS-CoV-2 convalescent participants tested over 394 timepoints, including 121 people experiencing Long COVID symptoms, had detectable IFN-α2 antibodies. Both had been hospitalized during the acute phase of the infection. These data suggest that persistent anti-IFN antibodies, although a potential driver of severe COVID-19, are unlikely to contribute to Long COVID symptoms in the post-acute phase of the infection.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
Topics:
Long Covid
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Infdis
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