Vitamin A in children's pneumonia for a COVID-19 perspective: A systematic review and meta-analysis of 15 trials.
Medicine (Baltimore)
; 101(42): e31289, 2022 Oct 21.
Article
in English
| MEDLINE | ID: covidwho-2087901
ABSTRACT
BACKGROUND:
To systematically review and meta-analyze the efficacy of vitamin A as an adjuvant therapy for pneumonia in children.METHODS:
We searched in PubMed, the Cochrane Library, Chinese National Knowledge Infrastructure, WanFang Database and Chongqing VIP information network from libraries building to March 2022, screening randomized controlled trials (RCT) about vitamin A combined with conventional therapy for pneumonia in children. Two researchers used the Cochrane risk of bias tool to assess the quality of included studies dependently. Data analysis was conducted in the RevMan 5.3.RESULTS:
15 trials involving 3496 patients (treated group 1898; control group 1598) were analyzed in this study. The Meta-analysis showed that vitamin A combined with conventional therapy improved clinical efficacy (Pâ <â .05), shortened the duration of fever and cough, negative time of chest X-ray, and the hospitalization, lung rale disappearance, choking milk disappearance, shortness of breath disappearance and perilabial cyanosis disappearance (Pâ <â .05). However, vitamin A combined with conventional therapy did not reduce the mortality of pneumonia in children (Pâ >â .05).CONCLUSION:
Vitamin A contributes to relieve the clinical symptoms and signs, and also shorten the hospitalization.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Child
/
Humans
Language:
English
Journal:
Medicine (Baltimore)
Year:
2022
Document Type:
Article
Affiliation country:
MD.0000000000031289
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