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SARS-CoV-2 seropositivity and HIV viral load among Mozambican pregnant women.
González, Raquel; Nhampossa, Tacilta; Figueroa-Romero, Antía; Mendes, Anete; Mazuze, Maura; García-Otero, Laura; Sevene, Esperança; Piqueras, Mireia; Egri, Natalia; Bedini, Josep Lluis; Saúte, Francisco; Menendez, Clara.
  • González R; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic- Universitat de Barcelona, Spain.
  • Nhampossa T; Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique.
  • Figueroa-Romero A; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP).
  • Mendes A; Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique.
  • Mazuze M; Instituto Nacional de Saúde, Ministério de Saúde, Mozambique.
  • García-Otero L; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic- Universitat de Barcelona, Spain.
  • Sevene E; Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique.
  • Piqueras M; Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique.
  • Egri N; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic- Universitat de Barcelona, Spain.
  • Bedini JL; Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Mozambique.
  • Saúte F; Eduardo Mondlane University, Faculty of medicine, Maputo, Mozambique.
  • Menendez C; Barcelona Institute for Global Health (ISGlobal), Hospital Clínic- Universitat de Barcelona, Spain.
J Acquir Immune Defic Syndr ; 2022 Oct 24.
Article in English | MEDLINE | ID: covidwho-2230459
ABSTRACT

INTRODUCTION:

Prevalence estimates of SARS-CoV-2 infection in Africa are limited, particularly among pregnant women and in those living with HIV. This study assessed the seroprevalence of SARS-CoV-2 antibodies among Mozambican HIV-infected pregnant women during the first year of the pandemic, before COVID-19 vaccines were deployed in the country.

SETTING:

The study was conducted in Manhiça district, a semi-rural area in southern Mozambique.

METHODS:

A prospective cohort study including pregnant women living with HIV was carried out from November 2019 to June 2021. Women were enrolled at the first antenatal care (ANC) clinic visit and followed until post-partum. HIV viral load (HIV-VL) and IgM/IgG antibodies against SARS-CoV-2 were determined in blood samples at first ANC clinic visit and at delivery. Associations between SARS-CoV-2 serostatus and maternal characteristics at enrolment were analysed.

RESULTS:

A total of 397 women were enrolled. SARS-CoV-2 IgG/IgM antibodies were detected in 7.1% of women at enrolment and in 8.5% of women at delivery. Overall, SARS-CoV-2 antibodies were detected in 45 (11.3%; 95%CI 8.4-14.9%) women during the study period; the first seropositive sample was identified in September 2020. Having undetectable HIV-VL was associated with seropositivity of SARS-CoV-2 IgG/IgM (OR 3.35 [1.10-11.29]; p=0.039).

CONCLUSION:

Seroprevalence of SARS-CoV-2 antibodies in this cohort of Mozambican unvaccinated pregnant women was similar to reported global estimates of approximately 10% in pregnancy for 2021. Findings also suggest that pregnant women with high HIV- viral load may have an impaired immune response against SARS-CoV-2 and might need to be carefully managed in case of COVID-19.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Language: English Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2022 Document Type: Article Affiliation country: QAI.0000000000003120

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Language: English Journal subject: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Year: 2022 Document Type: Article Affiliation country: QAI.0000000000003120