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Restoration of dendritic cell homeostasis and Type I/Type III interferon levels in convalescent COVID-19 individuals.
Rajamanickam, Anuradha; Kumar, Nathella Pavan; Pandiaraj, Arul Nancy; Selvaraj, Nandhini; Munisankar, Saravanan; Renji, Rachel Mariam; Venkatramani, Vijayalakshmi; Murhekar, Manoj; Thangaraj, Jeromie Wesley Vivian; Kumar, Muthusamy Santhosh; Kumar, Chethrapilly Purushothaman Girish; Bhatnagar, Tarun; Ponnaiah, Manickam; Sabarinathan, Ramasamy; Saravanakumar, Velusamy; Babu, Subash.
  • Rajamanickam A; ICER-ICMR-NIRT-International Center for Excellence in Research, Chennai, Tamil Nadu, India. anuradha@icerindia.org.
  • Kumar NP; Immunology-ICMR-National Institute for Research in Tuberculosis, Chennai, Tamil Nadu, India.
  • Pandiaraj AN; ICER-ICMR-NIRT-International Center for Excellence in Research, Chennai, Tamil Nadu, India.
  • Selvaraj N; ICER-ICMR-NIRT-International Center for Excellence in Research, Chennai, Tamil Nadu, India.
  • Munisankar S; ICER-ICMR-NIRT-International Center for Excellence in Research, Chennai, Tamil Nadu, India.
  • Renji RM; ICER-ICMR-NIRT-International Center for Excellence in Research, Chennai, Tamil Nadu, India.
  • Venkatramani V; ICER-ICMR-NIRT-International Center for Excellence in Research, Chennai, Tamil Nadu, India.
  • Murhekar M; ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Thangaraj JWV; ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Kumar MS; ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Kumar CPG; ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Bhatnagar T; ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Ponnaiah M; ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Sabarinathan R; ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Saravanakumar V; ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu, India.
  • Babu S; ICER-ICMR-NIRT-International Center for Excellence in Research, Chennai, Tamil Nadu, India.
BMC Immunol ; 23(1): 51, 2022 10 26.
Article in English | MEDLINE | ID: covidwho-2089161
ABSTRACT

BACKGROUND:

Plasmacytoid and myeloid dendritic cells play a vital role in the protection against viral infections. In COVID-19, there is an impairment of dendritic cell (DC) function and interferon secretion which has been correlated with disease severity.

RESULTS:

In this study, we described the frequency of DC subsets and the plasma levels of Type I (IFNα, IFNß) and Type III Interferons (IFNλ1), IFNλ2) and IFNλ3) in seven groups of COVID-19 individuals, classified based on days since RT-PCR confirmation of SARS-CoV2 infection. Our data shows that the frequencies of pDC and mDC increase from Days 15-30 to Days 61-90 and plateau thereafter. Similarly, the levels of IFNα, IFNß, IFNλ1, IFNλ2 and IFNλ3 increase from Days 15-30 to Days 61-90 and plateau thereafter. COVID-19 patients with severe disease exhibit diminished frequencies of pDC and mDC and decreased levels of IFNα, IFNß, IFNλ1, IFNλ2 and IFNλ3. Finally, the percentages of DC subsets positively correlated with the levels of Type I and Type III IFNs.

CONCLUSION:

Thus, our study provides evidence of restoration of homeostatic levels in DC subset frequencies and circulating levels of Type I and Type III IFNs in convalescent COVID-19 individuals.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: BMC Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: S12865-022-00526-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: BMC Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article Affiliation country: S12865-022-00526-z