COVID-19 Vaccine Development and Applications

ABSTRACT

This chapter discusses the strategies applied and steps followed for fast-track development of COVID-19 vaccines under different platforms and their applications. In this chapter we also discuss some gene delivery systems and their applications in gene-based COVID-19 vaccine development. Bioinformatics tools also played critical roles in the acceleration of COVID-19 vaccine development. Globally, many academic, government, bio-pharma, and non-profit organizations have collaborated to tackle this crisis. Developments of vaccines against SARS-CoV-2 that elicit protective immune responses are essential to prevent and mitigate the morbidity and mortality caused by SARS-CoV-2 infection. The immune system plays a pivotal role in the pathogenesis of SARS-CoV-2 infection;thus, understanding the immune response and the underlying mechanism is very crucial to develop successful prophylactic vaccines against the virus. The development of an effective vaccine requires a proper antigen and the delivery system to achieve robust cellular and humoral immune responses following vaccination. © 2022 selection and editorial matter, Yashwant V. Pathak;individual chapters, the contributors.