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Risk Factors for New Neurologic Diagnoses in Hospitalized Patients With COVID-19: A Case-Control Study in New York City.
Thakur, Kiran T; Chu, Victoria T; Hughes, Christine; Kim, Carla Y; Fleck-Derderian, Shannon; Barrett, Catherine E; Matthews, Elizabeth; Balbi, Alanna; Bilski, Amanda; Chomba, Mashina; Lieberman, Ori; Jacobson, Samuel D; Agarwal, Sachin; Roh, David; Park, Soojin; Ssonko, Vivian; Silver, Wendy G; Vargas, Wendy D; Geneslaw, Andrew; Bell, Michelle; Waters, Brandon; Rao, Agam; Claassen, Jan; Boehme, Amelia; Willey, Joshua Z; Elkind, Mitchell S V; Sobieszczyk, Magdalena E; Zucker, Jason; McCollum, Andrea; Sejvar, James.
  • Thakur KT; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Chu VT; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Hughes C; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Kim CY; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Fleck-Derderian S; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Barrett CE; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Matthews E; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Balbi A; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Bilski A; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Chomba M; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Lieberman O; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Jacobson SD; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Agarwal S; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Roh D; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Park S; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Ssonko V; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Silver WG; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Vargas WD; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Geneslaw A; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Bell M; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Waters B; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Rao A; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Claassen J; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Boehme A; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Willey JZ; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Elkind MSV; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Sobieszczyk ME; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Zucker J; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • McCollum A; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
  • Sejvar J; Department of Neurology (KTT, CYK, EM, A. Balbi, A. Bilski, MC, OL, SDJ, SA, DR, SP, VS, WGS, WDV, AG, MB, BW, JC, A. Boehme, JZW, MSVE), Columbia University Irving Medical Center-New York Presbyterian Hospital; United States Centers for Disease Control and Prevention (VTC, CH, SF-D, CEB, AR, AM, JS
Neurol Clin Pract ; 12(4): e66-e74, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-2089290
ABSTRACT
Background and

Objectives:

There have been numerous reports of neurologic manifestations identified in hospitalized patients infected with SARS-CoV-2, the virus that causes COVID-19. Here, we identify the spectrum of associated neurologic symptoms and diagnoses, define the time course of their development, and examine readmission rates and mortality risk posthospitalization in a multiethnic urban cohort.

Methods:

We identify the occurrence of new neurologic diagnoses among patients with laboratory-confirmed SARS-CoV-2 infection in New York City. A retrospective cohort study was performed on 532 cases (hospitalized patients with new neurologic diagnoses within 6 weeks of positive SARS-CoV-2 laboratory results between March 1, 2020, and August 31, 2020). We compare demographic and clinical features of the 532 cases with 532 controls (hospitalized COVID-19 patients without neurologic diagnoses) in a case-control study with one-to-one matching and examine hospital-related data and outcomes of death and readmission up to 6 months after acute hospitalization in a secondary case-only analysis.

Results:

Among the 532 cases, the most common new neurologic diagnoses included encephalopathy (478, 89.8%), stroke (66, 12.4%), and seizures (38, 7.1%). In the case-control study, cases were more likely than controls to be male (58.6% vs 52.8%, p = 0.05), had baseline neurologic comorbidities (36.3% vs 13.0%, p < 0.0001), and were to be treated in an intensive care unit (62.0% vs 9.6%, p < 0.0001). Of the 394 (74.1%) cases who survived acute hospitalization, more than half (220 of 394, 55.8%) were readmitted within 6 months, with a mortality rate of 23.2% during readmission.

Discussion:

Hospitalized patients with SARS-CoV-2 and new neurologic diagnoses have significant morbidity and mortality postdischarge. Further research is needed to define the effect of neurologic diagnoses during acute hospitalization on longitudinal post-COVID-19-related symptoms including neurocognitive impairment.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Neurol Clin Pract Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Language: English Journal: Neurol Clin Pract Year: 2022 Document Type: Article