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A potent inflammatory response is triggered in asymptomatic blood donors with recent SARS-CoV-2 infection.
Martins, Marina Lobato; Silva-Malta, Maria Clara Fernandes da; Araújo, Argus Leão; Gonçalves, Fabíola Araújo; Botelho, Maiara de Lourdes; Oliveira, Isabelle Rocha de; Boy, Luciana de Souza Madeira Ferreira; Moreira, Hélinse Medeiros; Barbosa-Stancioli, Edel Figueiredo; Ribeiro, Maísa Aparecida; Chaves, Daniel Gonçalves.
  • Martins ML; Fundação Centro de Hematologia e Hemoterapia de Minas Gerais/Hemominas, Belo Horizonte, MG, Brasil.
  • Silva-Malta MCFD; Fundação Centro de Hematologia e Hemoterapia de Minas Gerais/Hemominas, Belo Horizonte, MG, Brasil.
  • Araújo AL; Fundação Hospitalar do Estado de Minas Gerais, Hospital Eduardo de Menezes, Belo Horizonte, MG, Brasil.
  • Gonçalves FA; Fundação Hospitalar do Estado de Minas Gerais, Hospital Eduardo de Menezes, Belo Horizonte, MG, Brasil.
  • Botelho ML; Fundação Hospitalar do Estado de Minas Gerais, Hospital Eduardo de Menezes, Belo Horizonte, MG, Brasil.
  • Oliveira IR; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Virologia Básica e Aplicada, Belo Horizonte, MG, Brasil.
  • Boy LSMF; Fundação Centro de Hematologia e Hemoterapia de Minas Gerais/Hemominas, Belo Horizonte, MG, Brasil.
  • Moreira HM; Fundação Centro de Hematologia e Hemoterapia de Minas Gerais/Hemominas, Belo Horizonte, MG, Brasil.
  • Barbosa-Stancioli EF; Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia, Laboratório de Virologia Básica e Aplicada, Belo Horizonte, MG, Brasil.
  • Ribeiro MA; Fundação Centro de Hematologia e Hemoterapia de Minas Gerais/Hemominas, Belo Horizonte, MG, Brasil.
  • Chaves DG; Fundação Centro de Hematologia e Hemoterapia de Minas Gerais/Hemominas, Belo Horizonte, MG, Brasil.
Rev Soc Bras Med Trop ; 55: e02392022, 2022.
Article in English | MEDLINE | ID: covidwho-2089509
ABSTRACT

BACKGROUND:

The inflammatory response plays a significant role in the outcome of coronavirus disease (COVID-19).

METHODS:

We investigated plasma cytokine and chemokine concentrations in non-infected (NI), asymptomatic severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-infected blood donors (AS), and patients with severe COVID-19 (SC).

RESULTS:

The SC group showed significantly higher levels of interleukin 6 (IL-6), IL-10, and CCL5 than the AS and NI groups. The SC and AS groups had considerably greater CXCL9 and CXCL10 concentrations than the NI group. Only NI and infected people showed separate clusters in the principal component analysis.

CONCLUSIONS:

SC, as well as AS was characterized by an inflammatory profile.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Rev Soc Bras Med Trop Year: 2022 Document Type: Article Affiliation country: 0037-8682-0239-2022

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Rev Soc Bras Med Trop Year: 2022 Document Type: Article Affiliation country: 0037-8682-0239-2022