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SARS-CoV-2 specific antibody trajectories in mothers and infants over two months following maternal infection.
Martin, Melanie A; Keith, Monica; Pace, Ryan M; Williams, Janet E; Ley, Sylvia H; Barbosa-Leiker, Celestina; Caffé, Beatrice; Smith, Caroline B; Kunkle, Amanda; Lackey, Kimberly A; Navarrete, Alexandra D; Pace, Christina D W; Gogel, Alexandra C; Eisenberg, Dan T A; Fehrenkamp, Bethaney D; McGuire, Mark A; McGuire, Michelle K; Meehan, Courtney L; Brindle, Eleanor.
  • Martin MA; Department of Anthropology, University of Washington, Seattle, WA, United States.
  • Keith M; Center for Studies in Demography and Ecology, University of Washington, Seattle, WA, United States.
  • Pace RM; Department of Anthropology, University of Washington, Seattle, WA, United States.
  • Williams JE; Center for Studies in Demography and Ecology, University of Washington, Seattle, WA, United States.
  • Ley SH; Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
  • Barbosa-Leiker C; Department of Animal, Veterinary and Food Sciences, University of Idaho, Moscow, ID, United States.
  • Caffé B; Department of Epidemiology, Tulane University School of Public Health, New Orleans, LA, United States.
  • Smith CB; College of Nursing, Washington State University Health Sciences Spokane, Spokane, WA, United States.
  • Kunkle A; Department of Anthropology, Washington State University, Pullman, WA, United States.
  • Lackey KA; Department of Anthropology, Washington State University, Pullman, WA, United States.
  • Navarrete AD; Department of Anthropology, University of Washington, Seattle, WA, United States.
  • Pace CDW; Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
  • Gogel AC; Elson S. Floyd College of Medicine, Washington State University, Spokane, WA, United States.
  • Eisenberg DTA; Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
  • Fehrenkamp BD; Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
  • McGuire MA; Department of Anthropology, University of Washington, Seattle, WA, United States.
  • McGuire MK; Center for Studies in Demography and Ecology, University of Washington, Seattle, WA, United States.
  • Meehan CL; Margaret Ritchie School of Family and Consumer Sciences, University of Idaho, Moscow, ID, United States.
  • Brindle E; Washington, Wyoming, Alaska, Montana and Idaho (WWAMI) Medical Education, University of Idaho, Moscow, ID, United States.
Front Immunol ; 13: 1015002, 2022.
Article in English | MEDLINE | ID: covidwho-2089844
ABSTRACT
Infants exposed to caregivers infected with SARS-CoV-2 may have heightened infection risks relative to older children due to their more intensive care and feeding needs. However, there has been limited research on COVID-19 outcomes in exposed infants beyond the neonatal period. Between June 2020 - March 2021, we conducted interviews and collected capillary dried blood spots from 46 SARS-CoV-2 infected mothers and their infants (aged 1-36 months) for up to two months following maternal infection onset (COVID+ group, 87% breastfeeding). Comparative data were also collected from 26 breastfeeding mothers with no known SARS-CoV-2 infection or exposures (breastfeeding control group), and 11 mothers who tested SARS-CoV-2 negative after experiencing symptoms or close contact exposure (COVID- group, 73% breastfeeding). Dried blood spots were assayed for anti-SARS-CoV-2 S-RBD IgG and IgA positivity and anti-SARS-CoV-2 S1 + S2 IgG concentrations. Within the COVID+ group, the mean probability of seropositivity among infant samples was lower than that of corresponding maternal samples (0.54 and 0.87, respectively, for IgG; 0.33 and 0.85, respectively, for IgA), with likelihood of infant infection positively associated with the number of maternal symptoms and other household infections reported. COVID+ mothers reported a lower incidence of COVID-19 symptoms among their infants as compared to themselves and other household adults, and infants had similar PCR positivity rates as other household children. No samples returned by COVID- mothers or their infants tested antibody positive. Among the breastfeeding control group, 44% of mothers but none of their infants tested antibody positive in at least one sample. Results support previous research demonstrating minimal risks to infants following maternal COVID-19 infection, including for breastfeeding infants.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Child / Female / Humans / Infant / Infant, Newborn Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.1015002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Adolescent / Adult / Child / Female / Humans / Infant / Infant, Newborn Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.1015002