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Glycyrrhizin Inhibits SARS-CoV-2 Entry into Cells by Targeting ACE2.
He, Ming-Feng; Liang, Jian-Hui; Shen, Yan-Ni; Zhang, Jin-Wen; Liu, Ying; Yang, Kuang-Yang; Liu, Li-Chu; Wang, Junyi; Xie, Qian; Hu, Chun; Song, Xun; Wang, Yan.
  • He MF; Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China.
  • Liang JH; Center for Translation Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
  • Shen YN; Center for Translation Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
  • Zhang JW; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Liu Y; Center for Translation Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
  • Yang KY; College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
  • Liu LC; Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China.
  • Wang J; Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China.
  • Xie Q; Bluewood Associates Co., Ltd., Suzhou 215134, China.
  • Hu C; Center for Translation Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
  • Song X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
  • Wang Y; College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
Life (Basel) ; 12(11)2022 Oct 26.
Article in English | MEDLINE | ID: covidwho-2090267
ABSTRACT
Coronavirus Disease 2019 (COVID-19) is a highly infectious and pathogenic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early in this epidemic, the herbal formulas used in traditional Chinese medicine (TCM) were widely used for the treatment of COVID-19 in China. According to Venn diagram analysis, we found that Glycyrrhizae Radix et Rhizoma is a frequent herb in TCM formulas against COVID-19. The extract of Glycyrrhizae Radix et Rhizoma exhibits an anti-SARS-CoV-2 replication activity in vitro, but its pharmacological mechanism remains unclear. We here demonstrate that glycyrrhizin, the main active ingredient of Glycyrrhizae Radix et Rhizoma, prevents the coronavirus from entering cells by targeting angiotensin-converting enzyme 2 (ACE2). Glycyrrhizin inhibited the binding of the spike protein of the SARS-CoV-2 to ACE2 in our Western blot-based assay. The following bulk RNA-seq analysis showed that glycyrrhizin down-regulated ACE2 expression in vitro which was further confirmed by Western blot and quantitative PCR. Together, we believe that glycyrrhizin inhibits SARS-CoV-2 entry into cells by targeting ACE2.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Traditional medicine Language: English Year: 2022 Document Type: Article Affiliation country: Life12111706

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Full text: Available Collection: International databases Database: MEDLINE Topics: Traditional medicine Language: English Year: 2022 Document Type: Article Affiliation country: Life12111706