[Consideration on the possible etiological mechanisms and countermeasures about severe acute hepatitis of unknown origin in children].
Zhonghua Yu Fang Yi Xue Za Zhi
; 56(10): 1499-1504, 2022 Oct 06.
Article
in Chinese
| MEDLINE | ID: covidwho-2090419
ABSTRACT
Since April 2022, severe acute hepatitis of unknown origin in children has spread to 35 countries and regions around the world, and more than 1 010 cases have been reported. Since the severe acute hepatitis of unknown origin involves a wide range of areas and has a high rate, it is critical to identify the etiology and establish effective preventive, diagnostic and therapeutic measures as soon as possible. This study discusses the possible mechanisms and countermeasures of the severe acute hepatitis of unknown origin in children. It speculates that the occurrence of the recent severe acute hepatitis might be related to adenovirus, adeno-associated virus infection, and the COVID-19 epidemic, while the difference in HLA polymorphism among different races might be related to the fact that reported cases were more common in Europe and the United States. Based on the currently available evidence, it can be preliminarily judged that the risk of large-scale outbreak of severe acute hepatitis of unknown origin in children would be low in China, but the persistent awareness and vigilance of the etiology is still needed.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Hepatitis
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Country/Region as subject:
North America
/
Asia
Language:
Chinese
Journal:
Zhonghua Yu Fang Yi Xue Za Zhi
Year:
2022
Document Type:
Article
Affiliation country:
Cma.j.cn112150-20220603-00572
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