In-Silico Screening of Plant-Derived Natural Compounds for Their Anti- Covid-19 Potential
Journal of the Chilean Chemical Society
; 67(3):5656-5661, 2022.
Article
in English
| Web of Science | ID: covidwho-2092177
ABSTRACT
The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, in December 2019 and quickly spread across the worldwide. It becomes a global pandemic and risk to the healthcare system of almost every nation around the world. In this study thirty natural compounds of 19 Indian herbal plants were used to analyze their binding with eight proteins associated with CO VID-19. Based on the molecular docking as well as ADMET analysis, isovitexin, glycyrrhizin, sitosterol, and piperine were identified as potential herbal medicine candidates. On comparing the binding affinity with Ivermectin, we have found that the inhibition potentials of the Trigonella foenum-graecum (fenugreek), Glycyrrhiza glabra (licorice), Tinospora cordifolia (giloy) and Piper nigrum (black pepper) are very promising with no side-effects.
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Collection:
Databases of international organizations
Database:
Web of Science
Language:
English
Journal:
Journal of the Chilean Chemical Society
Year:
2022
Document Type:
Article
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