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Clinical Characteristics of Children With SARS-CoV-2 Infection During the Third Wave of the Pandemic: Single Center Experience.
Sarkar, Mihir; Ghosh, Ananya; Konar, Mithun Chandra; Roy, Oishik; Mahapatra, Manas Kumar; Nandi, Mousumi.
  • Sarkar M; Department of Pediatrics, Medical College and Hospital, Kolkata. Correspondence to: Dr Mihir Sarkar, 88, College Street, Department of Pediatrics, Medical College and Hospital, Kolkata, West Bengal 700 073. drmihir09@gmail.com.
  • Ghosh A; Department of Pediatrics, Medical College and Hospital, Kolkata.
  • Konar MC; Department of Pediatrics, Medical College and Hospital, Kolkata.
  • Roy O; Department of Pediatrics, Medical College and Hospital, Kolkata.
  • Mahapatra MK; Department of Pediatrics, Medical College and Hospital, Kolkata.
  • Nandi M; Department of Pediatrics, Medical College and Hospital, Kolkata.
Indian Pediatr ; 59(7): 531-534, 2022 07 15.
Article in English | MEDLINE | ID: covidwho-2092983
ABSTRACT

OBJECTIVE:

To evaluate pulmonary functions in children with transfusion-dependent thalassemia, and its reversal (lung dysfunction) using intensive intravenous chelation with desferrioxamine (DFO) (4 weeks).

METHODS:

This descriptive study enrolled 77 children with transfusion-dependent thalassemia. Pulmonary function test (PFT) and iron load (serum ferritin (SF) and T2* MRI of heart and liver) were done. PFT included spirometry, total lung capacity (TLC) by helium dilution test and diffusion capacity by carbon monoxide (DLCO). Follow-up PFT was available for 13 children with moderate to severe lung dysfunction given intravenous DFO.

RESULTS:

50 (68.8%) patients had lung dysfunction, most commonly diffusional impairment (48; 96%), and reduced TLC (11; 22%); and none had obstructive pattern. 9 (81.8%) patients with restrictive defect had moderate to severely deranged DLCO. PFT and T2* MRI values were inversely correlated with serum ferritin. Among 13 patients receiving intensive chelation for 4 weeks, significant improvement was noticed in forced expiratory volume in one minute/ forced vital capacity ratio (DFEV1/FVC) (P=0.009), DDLCO (P=0.006) and DSF (P=0.01).

CONCLUSIONS:

Pulmonary dysfunction is common in children with multi-transfused thalassemia, and routine screening by PFT needs to be part of the management guidelines.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Thalassemia / Beta-Thalassemia / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Child / Humans Language: English Journal: Indian Pediatr Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thalassemia / Beta-Thalassemia / COVID-19 Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Child / Humans Language: English Journal: Indian Pediatr Year: 2022 Document Type: Article