Socioeconomic and race/ethnic differences in immunosenescence: Evidence from the Health and Retirement Study.
Brain Behav Immun
; 107: 361-368, 2023 Jan.
Article
in English
| MEDLINE | ID: covidwho-2095083
ABSTRACT
BACKGROUND:
The COVID-19 pandemic has highlighted the urgent need to understand variation in immunosenescence at the population-level. Thus far, population patterns of immunosenescence have not well described.METHODS:
We characterized measures of immunosenescence from the 2016 Venous Blood Study from the nationally representative U.S Health and Retirement Study (HRS) of individuals ages 50 years and older.RESULTS:
Median values of the CD8+CD4+, EMRANaïve CD4+ and EMRANaïve CD8+ ratios were higher among older participants and were lower in those with additional educational attainment. Generally, minoritized race and ethnic groups had immune markers suggestive of a more aged immune profile Hispanics had a CD8+CD4+ median value of 0.37 (95 % CI 0.35, 0.39) compared to 0.30 in non-Hispanic Whites (95 % CI 0.29, 0.31). Non-Hispanic Blacks had the highest median value of the EMRANaïve CD4+ ratio (0.08; 95 % CI 0.07, 0.09) compared to non-Hispanic Whites (0.03; 95 % CI 0.028, 0.033). In regression analyses, race/ethnicity and education were associated with large differences in the immune ratio measures after adjustment for age and sex.CONCLUSIONS:
Lower educational attainment and minoritized racial ethnic status were associated with higher levels of immunosenescence. This population variation may have important implications for both risk of age-related disease and vulnerability to emerging pathogens (e.g., SARS-CoV-2).Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Academic Success
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
Limits:
Aged
/
Humans
/
Middle aged
Language:
English
Journal:
Brain Behav Immun
Journal subject:
Allergy and Immunology
/
Brain
/
Psychophysiology
Year:
2023
Document Type:
Article
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