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Extended SARS-CoV-2 RBD booster vaccination induces humoral and cellular immune tolerance in mice.
Gao, Feng-Xia; Wu, Rui-Xin; Shen, Mei-Ying; Huang, Jing-Jing; Li, Ting-Ting; Hu, Chao; Luo, Fei-Yang; Song, Shu-Yi; Mu, Song; Hao, Ya-Nan; Han, Xiao-Jian; Wang, Ying-Ming; Li, Luo; Li, Sheng-Long; Chen, Qian; Wang, Wang; Jin, Ai-Shun.
  • Gao FX; Department of Immunology, College of Basic Medicine, Chongqing Medical University, ChongQing 400010, China.
  • Wu RX; Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, ChongQing 400010, China.
  • Shen MY; Department of Immunology, College of Basic Medicine, Chongqing Medical University, ChongQing 400010, China.
  • Huang JJ; Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, ChongQing 400010, China.
  • Li TT; Department of Endocrine Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, ChongQing 400010, China.
  • Hu C; Department of Immunology, College of Basic Medicine, Chongqing Medical University, ChongQing 400010, China.
  • Luo FY; Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, ChongQing 400010, China.
  • Song SY; Department of Immunology, College of Basic Medicine, Chongqing Medical University, ChongQing 400010, China.
  • Mu S; Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, ChongQing 400010, China.
  • Hao YN; Department of Immunology, College of Basic Medicine, Chongqing Medical University, ChongQing 400010, China.
  • Han XJ; Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, ChongQing 400010, China.
  • Wang YM; Department of Immunology, College of Basic Medicine, Chongqing Medical University, ChongQing 400010, China.
  • Li L; Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, ChongQing 400010, China.
  • Li SL; Department of Immunology, College of Basic Medicine, Chongqing Medical University, ChongQing 400010, China.
  • Chen Q; Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, ChongQing 400010, China.
  • Wang W; Department of Immunology, College of Basic Medicine, Chongqing Medical University, ChongQing 400010, China.
  • Jin AS; Chongqing Key Laboratory of Basic and Translational Research of Tumor Immunology, Chongqing Medical University, ChongQing 400010, China.
iScience ; 25(12): 105479, 2022 Dec 22.
Article in English | MEDLINE | ID: covidwho-2095532
ABSTRACT
The repetitive applications of vaccine boosters have been brought up in face of continuous emergence of SARS-CoV-2 variants with neutralization escape mutations, but their protective efficacy and potential adverse effects remain largely unknown. Here, we compared the humoral and cellular immune responses of an extended course of recombinant receptor binding domain (RBD) vaccine boosters with those from conventional immunization strategy in a Balb/c mice model. Multiple vaccine boosters after the conventional vaccination course significantly decreased RBD-specific antibody titers and serum neutralizing efficacy against the Delta and Omicron variants, and profoundly impaired CD4+ and CD8+T cell activation and increased PD-1 and LAG-3 expressions in these T cells. Mechanistically, we confirmed that extended vaccination with RBD boosters overturned the protective immune memories by promoting adaptive immune tolerance. Our findings demonstrate potential risks with the continuous use of SARS-CoV-2 vaccine boosters, providing immediate implications for the global COVID-19 vaccination enhancement strategies.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines / Variants Language: English Journal: IScience Year: 2022 Document Type: Article Affiliation country: J.isci.2022.105479

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Topics: Vaccines / Variants Language: English Journal: IScience Year: 2022 Document Type: Article Affiliation country: J.isci.2022.105479