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Clinical findings of patients with coronavirus disease 2019 in Jiangsu province, China: A retrospective, multi-center study.
Huang, Rui; Zhu, Li; Xue, Leyang; Liu, Longgen; Yan, Xuebing; Wang, Jian; Zhang, Biao; Xu, Tianmin; Ji, Fang; Zhao, Yun; Cheng, Juan; Wang, Yinling; Shao, Huaping; Hong, Shuqin; Cao, Qi; Li, Chunyang; Zhao, Xiang-An; Zou, Lei; Sang, Dawen; Zhao, Haiyan; Guan, Xinying; Chen, Xiaobing; Shan, Chun; Xia, Juan; Chen, Yuxin; Yan, Xiaomin; Wei, Jie; Zhu, Chuanwu; Wu, Chao.
  • Huang R; Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
  • Zhu L; Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of Soochow University, Suzhou, China.
  • Xue L; Department of Critical Medicine, Huai'an No. 4 People's Hospital, Huai'an, China.
  • Liu L; Department of Infectious Diseases, The Third People's Hospital of Changzhou, Changzhou, China.
  • Yan X; Department of Infectious Diseases, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
  • Wang J; Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
  • Zhang B; Department of Quality Control Office, Huai'an No. 4 People's Hospital, Huai'an, China.
  • Xu T; Department of Infectious Diseases, The Third People's Hospital of Changzhou, Changzhou, China.
  • Ji F; Department of Infectious Diseases, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
  • Zhao Y; Department of Infectious Diseases, The Third People's Hospital of Yangzhou, Yangzhou, China.
  • Cheng J; Department of Infectious Diseases, Yancheng Second People's Hospital, Yancheng, China.
  • Wang Y; Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of Soochow University, Suzhou, China.
  • Shao H; Department of Infectious Diseases, The People's Hospital of Suqian, Suqian, China.
  • Hong S; Nursing Department, Huai'an No. 4 People's Hospital, Huai'an, China.
  • Cao Q; Department of Infectious Diseases, The Third People's Hospital of Changzhou, Changzhou, China.
  • Li C; Department of Infectious Diseases, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
  • Zhao XA; Department of Gastroenterology, Northern Jiangsu People's Hospital, Clinical Medical College of Yangzhou University, Yangzhou, China.
  • Zou L; Department of Infectious Diseases, Yancheng Second People's Hospital, Yancheng, China.
  • Sang D; Department of Infectious Diseases, Yancheng Second People's Hospital, Yancheng, China.
  • Zhao H; Department of Infectious Diseases, The People's Hospital of Suqian, Suqian, China.
  • Guan X; Department of Neurology, The Affiliated Hospital of Kangda College of Nanjing Medical University, The First People's Hospital of Lianyungang, Lianyungang, China.
  • Chen X; Department of Emergency, The Affiliated Hospital of Kangda College of Nanjing Medical University, The First People's Hospital of Lianyungang, Lianyungang, China.
  • Shan C; Department of Infectious Diseases, Zhongda Hospital Southeast University, Nanjing, China.
  • Xia J; Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
  • Chen Y; Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
  • Yan X; Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
  • Wei J; Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.
  • Zhu C; Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital of Soochow University, Suzhou, China.
  • Wu C; Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
PLoS Negl Trop Dis ; 14(5): e0008280, 2020 05.
Article in English | MEDLINE | ID: covidwho-209648
ABSTRACT
Limited data are available for clinical characteristics of patients with coronavirus disease 2019 (COVID-19) outside Wuhan. This study aimed to describe the clinical characteristics of COVID-19 and identify the risk factors for severe illness of COVID-19 in Jiangsu province, China. Clinical data of hospitalized COVID-19 patients were retrospectively collected in 8 hospitals from 8 cities of Jiangsu province, China. Clinical findings of COVID-19 patients were described and risk factors for severe illness of COVID-19 were analyzed. By Feb 10, 2020, 202 hospitalized patients with COVID-19 were enrolled. The median age of patients was 44.0 years (interquartile range, 33.0-54.0). 55 (27.2%) patients had comorbidities. At the onset of illness, the common symptoms were fever (156 [77.2%]) and cough (120 [59.4%]). 66 (32.7%) patients had lymphopenia. 193 (95.5%) patients had abnormal radiological findings. 11 (5.4%) patients were admitted to the intensive care unit and none of the patients died. 23 (11.4%) patients had severe illness. Severe illness of COVID-19 was independently associated with body mass index (BMI) ≥ 28 kg/m2 (odds ratio [OR], 9.219; 95% confidence interval [CI], 2.731 to 31.126; P<0.001) and a known history of type 2 diabetes (OR, 4.326; 95% CI, 1.059 to 17.668; P = 0.041). In this case series in Jiangsu Province, COVID-19 patients had less severe symptoms and had better outcomes than the initial COVID-19 patients in Wuhan. The BMI ≥ 28 kg/m2 and a known history of type 2 diabetes were independent risk factors of severe illness in patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: PLoS Negl Trop Dis Journal subject: Tropical Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pntd.0008280

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: PLoS Negl Trop Dis Journal subject: Tropical Medicine Year: 2020 Document Type: Article Affiliation country: Journal.pntd.0008280