Knowledge-based structural models of SARS-CoV-2 proteins and their complexes with potential drugs.
FEBS Lett
; 594(12): 1960-1973, 2020 06.
Article
in English
| MEDLINE | ID: covidwho-209663
ABSTRACT
The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID-19) caused by the novel coronavirus SARS-CoV-2 a pandemic. There is, however, no confirmed anti-COVID-19 therapeutic currently. In order to assist structure-based discovery efforts for repurposing drugs against this disease, we constructed knowledge-based models of SARS-CoV-2 proteins and compared the ligand molecules in the template structures with approved/experimental drugs and components of natural medicines. Our theoretical models suggest several drugs, such as carfilzomib, sinefungin, tecadenoson, and trabodenoson, that could be further investigated for their potential for treating COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Viral Proteins
/
Betacoronavirus
Language:
English
Journal:
FEBS Lett
Year:
2020
Document Type:
Article
Affiliation country:
1873-3468.13806
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