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Ultrasensitive NO Sensor Based on a Nickel Single-Atom Electrocatalyst for Preliminary Screening of COVID-19.
Zhou, Wei; Tan, Yi; Ma, Jing; Wang, Xiao; Yang, Li; Li, Zhen; Liu, Chengcheng; Wu, Hao; Sun, Lei; Deng, Weiqiao.
  • Zhou W; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao266237, China.
  • Tan Y; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao266237, China.
  • Ma J; Department of Critical Care Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan430070, Hubei, China.
  • Wang X; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao266237, China.
  • Yang L; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao266237, China.
  • Li Z; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao266237, China.
  • Liu C; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao266237, China.
  • Wu H; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao266237, China.
  • Sun L; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao266237, China.
  • Deng W; Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao266237, China.
ACS Sens ; 7(11): 3422-3429, 2022 Nov 25.
Article in English | MEDLINE | ID: covidwho-2096637
ABSTRACT
A new coronavirus, SARS-CoV-2, has caused the coronavirus disease-2019 (COVID-19) epidemic. A rapid and economical method for preliminary screening of COVID-19 may help to control the COVID-19 pandemic. Here, we report a nickel single-atom electrocatalyst that can be printed on a paper-printing sensor for preliminary screening of COVID-19 suspects by efficient detection of fractional exhaled nitric oxide (FeNO). The FeNO value is confirmed to be related to COVID-19 in our exploratory clinical study, and a machine learning model that can accurately classify healthy subjects and COVID-19 patients is established based on FeNO and other features. The nickel single-atom electrocatalyst consists of a single nickel atom with N2O2 coordination embedded in porous acetylene black (named Ni-N2O2/AB). A paper-printed sensor was fabricated with the material and showed ultrasensitive response to NO in the range of 0.3-180 ppb. This ultrasensitive sensor could be applied to preliminary screening of COVID-19 in everyday life.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Breath Tests / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: ACS Sens Year: 2022 Document Type: Article Affiliation country: Acssensors.2c01597

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Breath Tests / COVID-19 Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: ACS Sens Year: 2022 Document Type: Article Affiliation country: Acssensors.2c01597