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Discordant Antibody and T-Cell Responses to the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in Coronavirus Disease 2019 Messenger RNA Vaccine Recipients.
Woldemeskel, Bezawit A; Garliss, Caroline C; Aytenfisu, Tihitina Y; Johnston, Trevor S; Cox, Andrea L; Karaba, Andrew H; Blankson, Joel N.
  • Woldemeskel BA; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Garliss CC; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Aytenfisu TY; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Johnston TS; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Cox AL; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Karaba AH; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
  • Blankson JN; Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA.
Clin Infect Dis ; 75(9): 1652-1654, 2022 Oct 29.
Article in English | MEDLINE | ID: covidwho-2097327
ABSTRACT
We compared antibody and T-cell responses against the severe acute respiratory syndrome coronavirus 2 vaccine strain spike protein to responses against the Omicron variant in 15 messenger RNA vaccine recipients. While these individuals had significantly lower levels of antibodies that inhibited Omicron spike protein binding to ACE2, there was no difference in T-cell responses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid