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Successful treatment of prolonged, severe COVID-19 lower respiratory tract disease in a B-cell ALL patient with an extended course of remdesivir and nirmatrelvir/ritonavir.
Ford, Emily S; Simmons, William; Karmarkar, Ellora N; Yoke, Leah H; Braimah, Ayodale B; Orozco, Johnnie J; Ghiuzeli, Cristina M; Barnhill, Serena; Sack, Coralynn L; Benditt, Joshua O; Roychoudhury, Pavitra; Greninger, Alexander L; Shapiro, Adrienne E; Hammond, Jennifer L; Rusnak, James M; Dolsten, Mikael; Boeckh, Michael; Liu, Catherine; Cheng, Guang-Shing; Corey, Lawrence.
  • Ford ES; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington.
  • Simmons W; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center.
  • Karmarkar EN; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington.
  • Yoke LH; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington.
  • Braimah AB; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington.
  • Orozco JJ; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center.
  • Ghiuzeli CM; Division of General Internal Medicine, Department of Medicine, University of Washington.
  • Barnhill S; Clinical Research Division, Fred Hutchinson Cancer Center.
  • Sack CL; Division of Medical Oncology, Department of Medicine, University of Washington.
  • Benditt JO; Clinical Research Division, Fred Hutchinson Cancer Center.
  • Roychoudhury P; Division of Hematology, Department of Medicine, University of Washington.
  • Greninger AL; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington.
  • Shapiro AE; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington.
  • Hammond JL; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington.
  • Rusnak JM; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center.
  • Dolsten M; Department of Laboratory Medicine, University of Washington.
  • Boeckh M; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center.
  • Liu C; Department of Laboratory Medicine, University of Washington.
  • Cheng GS; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington.
  • Corey L; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center.
Clin Infect Dis ; 2022 Nov 03.
Article in English | MEDLINE | ID: covidwho-2259411
ABSTRACT
A patient with B-cell acute lymphoblastic leukemia (ALL) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had persistent, progressive pneumonia with viremia after 5 months of infection despite monoclonal antibodies, IV remdesivir and prolonged oral steroids. Twenty days of nirmatrelvir/ritonavir and 10 days of IV remdesivir led to full recovery.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Communicable Diseases Year: 2022 Document Type: Article