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Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study.
Chandna, Arjun; Mahajan, Raman; Gautam, Priyanka; Mwandigha, Lazaro; Kumar, Pragya; Varghese, George M; Koshiaris, Constantinos; Lubell, Yoel; Burza, Sakib.
  • Chandna A; Cambodia Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia.
  • Mahajan R; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.
  • Gautam P; Médecins Sans Frontières, New Delhi, India.
  • Mwandigha L; Department of Infectious Diseases, Christian Medical College, Vellore, India.
  • Varghese GM; Department of Community and Family Medicine, All India Institute of Medical Sciences, Patna, India.
  • Koshiaris C; Department of Infectious Diseases, Christian Medical College, Vellore, India.
  • Lubell Y; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.
  • Burza S; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.
Open Forum Infect Dis ; 9(10): ofac526, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2097435
ABSTRACT
Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)-1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2022 Document Type: Article Affiliation country: Ofid