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MOG-IgG positive optic neuritis after SARS-CoV-2 infection.
Gilardi, Marta; Cortese, Antonio; Ferraro, Elisabetta; Rispoli, Marco; Sadun, Riccardo; Altavista, Maria Concetta; Sadun, Federico.
  • Gilardi M; Neuro-Ophthalmology Unit, 220411Presidio Ospedaliero Oftalmico, Rome, Italy.
  • Cortese A; Multiple Sclerosis Centre, 18660Presidio Ospedaliero San Filippo Neri, Rome, Italy.
  • Ferraro E; Multiple Sclerosis Centre, 18660Presidio Ospedaliero San Filippo Neri, Rome, Italy.
  • Rispoli M; Neuro-Ophthalmology Unit, 220411Presidio Ospedaliero Oftalmico, Rome, Italy.
  • Sadun R; 60234Università Cattolica del Sacro Cuore School of Medicine, Rome, Italy.
  • Altavista MC; Neurology Unit, 18660Presidio Ospedaliero San Filippo Neri, Rome, Italy.
  • Sadun F; Neuro-Ophthalmology Unit, 220411Presidio Ospedaliero Oftalmico, Rome, Italy.
Eur J Ophthalmol ; : 11206721221136319, 2022 Nov 01.
Article in English | MEDLINE | ID: covidwho-2098241
ABSTRACT

BACKGROUND:

Many neurologic complications have been described after severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) including atypical cases of optic neuritis (ON), positive to myelin oligodendrocyte glycoprotein (MOG) IgG.

OBJECTIVE:

To report a case of MOG-IgG-associated ON and discuss why SARS-CoV-2 infection could be a potential trigger.

METHODS:

Retrospective single case report.

RESULTS:

We report a case of ON with positive MOG-IgG developed 15 days after presentation of SARS-CoV-2 infection.

CONCLUSION:

This report suggests that SARS-CoV-2 infection may have triggered autoantibodies production against MOG leading to ON.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Journal: Eur J Ophthalmol Journal subject: Ophthalmology Year: 2022 Document Type: Article Affiliation country: 11206721221136319

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Journal: Eur J Ophthalmol Journal subject: Ophthalmology Year: 2022 Document Type: Article Affiliation country: 11206721221136319