Arsenic intoxication: general aspects and chelating agents.
Arch Toxicol
; 94(6): 1879-1897, 2020 06.
Article
in English
| MEDLINE | ID: covidwho-209836
ABSTRACT
Arsenic (As) is widely used in the modern industry, especially in the production of pesticides, herbicides, wood preservatives, and semiconductors. The sources of As such as contaminated water, air, soil, but also food, can cause serious human diseases. The complex mechanism of As toxicity in the human body is associated with the generation of free radicals and the induction of oxidative damage in the cell. One effective strategy in reducing the toxic effects of As is the usage of chelating agents, which provide the formation of inert chelator-metal complexes with their further excretion from the body. This review discusses different aspects of the use of metal chelators, alone or in combination, in the treatment of As poisoning. Consideration is given to the therapeutic effect of thiol chelators such as meso-2,3-dimercaptosuccinic acid, sodium 2,3-dimercapto-1-propanesulfonate, 2,3-dimercaptopropanol, penicillamine, ethylenediaminetetraacetic acid, and other recent agents against As toxicity. The review also considers the possible role of flavonoids, trace elements, and herbal drugs as promising natural chelating and detoxifying agents.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Arsenicals
/
Chelating Agents
/
Arsenic Poisoning
/
Plant Preparations
/
Environmental Pollutants
/
Antidotes
Type of study:
Prognostic study
Topics:
Traditional medicine
Limits:
Animals
/
Humans
Language:
English
Journal:
Arch Toxicol
Year:
2020
Document Type:
Article
Affiliation country:
S00204-020-02739-w
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