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Metabolic disorders and post-acute hospitalization in black/mixed-race patients with long COVID in Brazil: A cross-sectional analysis.
Barreto, Ana Paula Andrade; Barreto Filho, Marcio Andrade; Duarte, Lucimeire Cardoso; Cerqueira-Silva, Thiago; Camelier, Aquiles; Tavares, Natalia Machado; Barral-Netto, Manoel; Boaventura, Viviane; Lima, Marcelo Chalhoub Coelho.
  • Barreto APA; Hospital Especializado Octávio Mangabeira (HEOM), Salvador, Brazil.
  • Barreto Filho MA; Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil.
  • Duarte LC; Hospital Especializado Octávio Mangabeira (HEOM), Salvador, Brazil.
  • Cerqueira-Silva T; Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil.
  • Camelier A; Hospital Especializado Octávio Mangabeira (HEOM), Salvador, Brazil.
  • Tavares NM; Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil.
  • Barral-Netto M; Instituto Gonçalo Moniz (Fiocruz-Bahia), Salvador, Brazil.
  • Boaventura V; Universidade Federal da Bahia (UFBA), Salvador, Brazil.
  • Lima MCC; Hospital Especializado Octávio Mangabeira (HEOM), Salvador, Brazil.
PLoS One ; 17(10): e0276771, 2022.
Article in English | MEDLINE | ID: covidwho-2098757
ABSTRACT

BACKGROUND:

Although low-middle income countries have been disproportionately affected by the COVID-19 pandemic, there is scarce information about the impact of long COVID on their population. This study aimed to evaluate long COVID symptomatology, complications (hospital readmission and metabolic disorders), and main clinical features that impact Quality of Life (QoL).

METHODS:

This cross-sectional study provides a detailed clinical and laboratory picture of individuals who presented residual symptoms after mild to severe acute COVID-19. Between Aug-2020 to Sep-2021, long COVID patients were evaluated in a reference center for long COVID in Bahia State, Brazil. The EQ-5D-5L questionnaire accessed QoL.

RESULTS:

A total of 1164 (52 ±13.4 years, 57% female, 88% black/mixed-race) were evaluated 2.3 [IQR = 1.6-3.7] months after mild (n = 351, 30.2%), moderate (338, 29.0%) or severe (475, 40.8%) acute illness. Dyspnea (790, 67.9%), fatigue (738, 63.5%), and chest pain (525, 42.9%) were the most frequent residual symptoms regardless of acute severity, affecting the QoL of 88.9% of patients (n/N-826/925), mainly the domains of anxiety/depression and pain/discomfort. High levels of HbA1c were detected for 175 out of 664 patients (26.6%), 40% of them without a previous diagnosis of diabetes mellitus. Of note, hospital admission one-to-three months after the acute phase of disease was required for 51 (4.4%) patients.

CONCLUSION:

In this majority-black/mixed-race population, long COVID was associated with post-acute hospitalization, newly diagnosed diabetes mellitus, and decreased QoL, particularly in women and regardless of disease severity of acute infection, suggesting important implications for health care system.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Metabolic Diseases Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0276771

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Metabolic Diseases Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Journal.pone.0276771