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COVID-19 Vaccination-Induced Ventricular Fibrillation in an Afebrile Patient With Brugada Syndrome.
Lim, Kyung Hee; Park, Jong-Sung.
  • Lim KH; Department of Cardiology, Dong-A University Hospital, Busan, Korea.
  • Park JS; Department of Cardiology, Dong-A University Hospital, Busan, Korea. thinkmed@dau.ac.kr.
J Korean Med Sci ; 37(42): e306, 2022 Oct 31.
Article in English | MEDLINE | ID: covidwho-2099100
ABSTRACT
A 43-year-old man presented with cardiac arrest 2 days after the second coronavirus disease 2019 (COVID-19) vaccination with an mRNA vaccine. Electrocardiograms showed ventricular fibrillation and type 1 Brugada pattern ST segment elevation. The patient reported having no symptoms, including febrile sensation. There were no known underlying cardiac diseases to explain such electrocardiographic abnormalities. ST segment elevation completely disappeared in two weeks. Although there were no genetic mutations or personal or family history typical of Brugada syndrome, flecainide administration induced type 1 Brugada pattern ST segment elevation. This case suggests that COVID-19 vaccination may induce cardiac ion channel dysfunction and cause life threatening ventricular arrhythmias in specific patients with Brugada syndrome.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brugada Syndrome / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Topics: Vaccines Limits: Adult / Humans / Male Language: English Journal: J Korean Med Sci Journal subject: Medicine Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Brugada Syndrome / COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Topics: Vaccines Limits: Adult / Humans / Male Language: English Journal: J Korean Med Sci Journal subject: Medicine Year: 2022 Document Type: Article