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STING Targeting in Lung Diseases.
de Moura Rodrigues, Dorian; Lacerda-Queiroz, Norinne; Couillin, Isabelle; Riteau, Nicolas.
  • de Moura Rodrigues D; Experimental and Molecular Immunology and Neurogenetics Laboratory, University of Orleans, Centre National de la Recherche Scientifique (CNRS), UMR7355, 45100 Orleans, France.
  • Lacerda-Queiroz N; Key-Obs: Preclinical CRO, 45100 Orleans, France.
  • Couillin I; Experimental and Molecular Immunology and Neurogenetics Laboratory, University of Orleans, Centre National de la Recherche Scientifique (CNRS), UMR7355, 45100 Orleans, France.
  • Riteau N; Experimental and Molecular Immunology and Neurogenetics Laboratory, University of Orleans, Centre National de la Recherche Scientifique (CNRS), UMR7355, 45100 Orleans, France.
Cells ; 11(21)2022 Nov 03.
Article in English | MEDLINE | ID: covidwho-2099367
ABSTRACT
The cGAS-STING pathway displays important functions in the regulation of innate and adaptive immunity following the detection of microbial and host-derived DNA. Here, we briefly summarize biological functions of STING and review recent literature highlighting its important contribution in the context of respiratory diseases. Over the last years, tremendous progress has been made in our understanding of STING activation, which has favored the development of STING agonists or antagonists with potential therapeutic benefits. Antagonists might alleviate STING-associated chronic inflammation and autoimmunity. Furthermore, pharmacological activation of STING displays strong antiviral properties, as recently shown in the context of SARS-CoV-2 infection. STING agonists also elicit potent stimulatory activities when used as an adjuvant promoting antitumor responses and vaccines efficacy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment / Membrane Proteins Topics: Vaccines Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11213483

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment / Membrane Proteins Topics: Vaccines Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Cells11213483