Your browser doesn't support javascript.
COVID-19 Molecular Pathophysiology: Acetylation of Repurposing Drugs.
Lee, Jong Hoon; Kanwar, Badar; Khattak, Asif; Balentine, Jenny; Nguyen, Ngoc Huy; Kast, Richard E; Lee, Chul Joong; Bourbeau, Jean; Altschuler, Eric L; Sergi, Consolato M; Nguyen, Tuan Ngoc Minh; Oh, Sangsuk; Sohn, Mun-Gi; Coleman, Michael.
  • Lee JH; Science and Research Center, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 03080, Korea.
  • Kanwar B; Department of Intensive Care Unit and Neonatal Intensive Care, Hunt Regional Hospital, Greenville, 75401 TX, USA.
  • Khattak A; Department of Intensive Care Unit and Neonatal Intensive Care, Hunt Regional Hospital, Greenville, 75401 TX, USA.
  • Balentine J; Department of Intensive Care Unit and Neonatal Intensive Care, Hunt Regional Hospital, Greenville, 75401 TX, USA.
  • Nguyen NH; Department of Health, Phutho Province, Tran Phu Str., Viet Tri City 227, Vietnam.
  • Kast RE; IIAIGC Study Center, Burlington, VT 05408, USA.
  • Lee CJ; Department of Anesthesiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.
  • Bourbeau J; Respiratory Epidemiology and Clinical Research Unit, McGill University Health Centre, Montréal, QC H4A 3S5, Canada.
  • Altschuler EL; Department of Physical Medicine and Rehabilitation, Metropolitan Hospital, New York, NY 10029, USA.
  • Sergi CM; Division of Anatomical Pathology, Children's Hospital of Eastern Ontario (CHEO), University of Ottawa, 401 Smyth Road, Ottawa, ON K1H 8L1, Canada.
  • Nguyen TNM; General Hospital of Phutho, Nguyen Tat Thanh, Str., Viet Tri City 227, Vietnam.
  • Oh S; Department of Food Engineering, Food Safety Laboratory, Memory Unit, Ewha Womans University, Seoul 03600, Korea.
  • Sohn MG; Department of Food Science, KyungHee University College of Life Science, Seoul 17104, Korea.
  • Coleman M; College of Health and Life Sciences, Aston University, Birmingham B4 7ET, UK.
Int J Mol Sci ; 23(21)2022 Oct 31.
Article in English | MEDLINE | ID: covidwho-2099576
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated type 1 interferon (IFN-1) production, the pathophysiology of which involves sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) tetramerization and the cytosolic DNA sensor cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway. As a result, type I interferonopathies are exacerbated. Aspirin inhibits cGAS-mediated signaling through cGAS acetylation. Acetylation contributes to cGAS activity control and activates IFN-1 production and nuclear factor-κB (NF-κB) signaling via STING. Aspirin and dapsone inhibit the activation of both IFN-1 and NF-κB by targeting cGAS. We define these as anticatalytic mechanisms. It is necessary to alleviate the pathologic course and take the lag time of the odds of achieving viral clearance by day 7 to coordinate innate or adaptive immune cell reactions.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferon Type I / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Year: 2022 Document Type: Article