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The Contribution of Diet Therapy and Probiotics in the Treatment of Sarcopenia Induced by Prolonged Immobilization Caused by the COVID-19 Pandemic.
Nistor-Cseppento, Carmen Delia; Moga, Titus David; Bungau, Alexa Florina; Tit, Delia Mirela; Negrut, Nicoleta; Pasca, Bianca; Bochis, Calin Florin; Ghitea, Timea Claudia; Jurcau, Anamaria; Purza, Anamaria Lavinia; Uivarosan, Diana.
  • Nistor-Cseppento CD; Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
  • Moga TD; Department of Morphological Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
  • Bungau AF; Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
  • Tit DM; Doctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
  • Negrut N; Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
  • Pasca B; Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
  • Bochis CF; Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
  • Ghitea TC; Clinical Oro-Maxillo-Facial Surgery, Clinical Emergency Municipal Hospital Timisoara, 300062 Timișoara, Romania.
  • Jurcau A; Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
  • Purza AL; Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania.
  • Uivarosan D; Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania.
Nutrients ; 14(21)2022 Nov 07.
Article in English | MEDLINE | ID: covidwho-2099683
ABSTRACT
The prolonged immobilization associated with COVID-19 infection and the restrictions imposed by the pandemic have determined major changes in physical activity and eating habits, with a negative impact on physical performance. This study monitored non-pharmacological interventions (diet therapy and probiotics) in managing sarcopenia for patients with recent SARS-CoV-2 history (14 days). A prospective study was performed on 200 patients (between December 2020-December 2021), with SPPB score < 9, randomly divided into Group K-DP (93 patients) with dietary therapy (protein 1.2-1.5 g/kg) and probiotics for two months; and Group K-non-DP (107 patients) without diet therapy and probiotics. All patients were included in a specific physical training program (40 min), three sessions per week. Skeletal muscle index (SMI), serum albumin, and hemoglobin were determined. The SMI was initially low for both groups without significant statistical differences (6.5 ± 0.52 kg/m2 for Group K-non-DP vs. 6.7 ± 0.57 Kg/m2 for Group K-DP, p = 0.135). After two months, significant difference between initial and final SMI values was determined for Group K-DP (6.92 ± 0.50 kg/m2 vs. 6.77 ± 0.56 kg/m2, p = 0.048). In Group K-DP, at end of study, were more patients with normal SMI (n = 32 → N = 70) values (p < 0.001) and fewer sarcopenia patients (p < 0.001). The initial serum albumin means values in the two groups (Group K-non-DP, 4.17 ± 1.04 g/dL, and Group K-DP, 3.95 ± 0.98 g/dL) were not statistically significantly different (p = 0.122). The hemoglobin level improved significantly following a hyper protein diet enriched with pro-biotics (p = 0.003). Diet therapy, consisting of increased protein intake and specific probiotics and specific physical therapy, demonstrated superiority in improving the functional status of patients with recent COVID-19 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Probiotics / Sarcopenia / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Nu14214701

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Probiotics / Sarcopenia / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: Nu14214701