Obesity a risk factor for increased COVID19 prevalence, severity and lethality (Review).
Mol Med Rep
; 22(1): 9-19, 2020 07.
Article
in English
| MEDLINE | ID: covidwho-209976
ABSTRACT
Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are a group of viruses that cause infections in the human respiratory tract, which can be characterized clinically from mild to fatal. The severe acute respiratory syndrome coronavirus 2 (SARSCoV2) is the virus responsible. The global spread of COVID19 can be described as the worst pandemic in humanity in the last century. To date, COVID19 has infected more than 3,000,000 people worldwide and killed more than 200,000 people. All age groups can be infected from the virus, but more serious symptoms that can possibly result in death are observed in older people and those with underlying medical conditions such as cardiovascular and pulmonary disease. Novel data report more severe symptoms and even a negative prognosis for the obese patients. A growing body of evidence connects obesity with COVID19 and a number of mechanisms from immune system activity attenuation to chronic inflammation are implicated. Lipid peroxidation creates reactive lipid aldehydes which in a patient with metabolic disorder and COVID19 will affect its prognosis. Finally, pregnancyassociated obesity needs to be studied further in connection to COVID19 as this infection could pose high risk both to pregnant women and the fetus.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Betacoronavirus
/
Obesity
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Topics:
Long Covid
Language:
English
Journal:
Mol Med Rep
Year:
2020
Document Type:
Article
Affiliation country:
Mmr.2020.11127
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