Clinical outcomes in vaccinated and unvaccinated patients with COVID-19: a population-based analysis.
Eur Rev Med Pharmacol Sci
; 26(20): 7705-7712, 2022 Oct.
Article
in English
| MEDLINE | ID: covidwho-2100860
ABSTRACT
OBJECTIVE:
Real-life data for vaccination against COVID-19 are sorely needed. This was a population-based analysis aiming at investigating the hospitalization risk for COVID-19 of 98,982 subjects and compare features of vaccinated and unvaccinated patients. PATIENTS ANDMETHODS:
Hospitalized patients with COVID-19 between 01/07/2021 and 11/02/2022 were included in the study.RESULTS:
582 patients were included in the analysis [males 58.6% (n=341), vaccinated patients 28.5% (n=166), unvaccinated patients 71.5% (n=416)]. Median age of vaccinated patients was significantly higher compared to median age of unvaccinated [74.0 (95% CI 72.0-77.0) vs. 59.0 (95% CI 57.0-62.0), p=0.0001]. Mean latency time (±SD) from the second dose to hospitalization was 5.7±2.6 months. Between 01/07/2021 and 01/12/2021, unvaccinated subjects had higher risk for hospitalization compared to vaccinated [HR 2.82, 95% CI 2.30-3.45, p<0.0001]. Between 02/12/2021 and 11/02/2022, unvaccinated subjects presented with higher risk for hospitalization than subjects that had received booster dose [HR 2.07, 95% CI 1.44-2.98, p=0.005], but not than subjects that got two doses. Median value of hospitalization days was higher in unvaccinated patients compared to vaccinated [7.0 (95% CI 7.0-8.0) vs. 6.0 (95% CI 5.0-7.0), p=0.02]. Finally, age-adjusted analysis showed that hospitalized unvaccinated patients presented with significantly higher mortality risk compared to hospitalized vaccinated patients [HR 2.59, 95% CI 1.69-3.98, p<0.0001].CONCLUSIONS:
Vaccination against COVID-19 remains the best way to contain the pandemic. There is an amenable need for booster dose during the omicron era.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Prognostic study
Topics:
Vaccines
/
Variants
Limits:
Humans
/
Male
Language:
English
Journal:
Eur Rev Med Pharmacol Sci
Journal subject:
Pharmacology
/
Toxicology
Year:
2022
Document Type:
Article
Affiliation country:
Eurrev_202210_30047
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