Association OF ACE2, AT1R genes with COVID-19 and diabetes Mellitus

ABSTRACT

Covid-19 Coronavirus has the highest transmission rate and mortality risk compared to other pandemic illnesses. Diabetes, on the other hand, was one of the most common disorders among people. As a result, diabetes patients infected with covid-19 are the persons who are most afflicted by the condition when compared to others. The present study was aimed to elucidate the association between covid-19 infection and type 2 Diabetes mellitus patients. The findings of thisstudy referto the association between Covid-19 patients with diabetes and patients with Covid-19 only. A case study was conducted between October-December (2021) on samples of COVID-19 and COVID-19+ diabetes. cases were collected in Babylon from Marjan Medical Hospital and Turkish Teaching Hospital. The number of samples was 92 samples, 31 blood samples from healthy people (3 females, 28 males), 30 samples infected with COVID19 (16 females, 14 males), and 31 samples infected with COVID-19+ diabetes mellitus (16 females, 14 males). The results showed the distribution of ACE2, AT1R genes of control, covid-19 patients, and diabetes mellitus patients infected with covid-19. where the ACE2 (ID;DD) group showed significant differences in three groups while the II and I groups don’t show any significant differences, the statistical analysis was made according to qi-square at (p-value≤ 0.05). The ACE2 D genotype was the dominant genotype (72.6%, 85%, and 54%) for the control, covid-19, and diabetes with covid-19 respectively, followed by DD, ID and I genotypes. And in the AT1R gene showed that DNA polymorphism between control and patientsthe findingsshow that there is no link between DNA polymorphisms and the number of bands in patients as compared to the control groups. There were significant differences (P-value ≤ 0.01) between control, COVID-19 patients, and COVID-19 diabetic patients in terms of AT1R polymorphism frequencies We observed that diabetes mellitus patients infected with Covid-19 had a much higher level of inflammatory proteins and diabetes-related parameters than patients infected with Covid-19 alone, rendering them more prone to illness and mortality. © 2022, ResearchTrentz Academy Publishing Education Services. All rights reserved.