Utility and Diagnostic Test Properties of Pulmonary and Cardiovascular Point of Care Ultra-sonography (POCUS) in COVID-19 patients admitted to critical care unit

ABSTRACT

Background We conducted this study to assess the diagnostic test properties of point of care ultrasonography (POCUS) of lung and cardiovascular system in prediction of mortality in COVID-19 patients. Methods This is a cross-sectional study of 178 Covid-19 patients;POCUS was performed within one hour of admission to the ICU. We estimated sensitivity, specificity, positive predictive value, negative predictive value for prediction of mortality. Results The mean (SD) age of these patients was 57.3 (12.8) years. The findings were on cardiac ultrasonography were mild pericardial effusion (45%), chamber dilatation (15%), hypokinesia (11%), and low ejection fraction (8%). In our study, 30 patients (17%) had died. A cut-off score of > to 13 (for lung ultrasound score [LUS]) had high sensitivity for mortality (93.3%, 95% CI 77.9% to 99.2%). However, low ejection fraction (92.3%, 95% CI 86,6% to 96.1%), and thrombosis in either vein (96.5%, 95% CI 92.0% to 98.9%) were specific for mortality. A combination of LUS >=13 or low ejection fraction or thrombosis or spontaneous echo contrast (slow flow) improved sensitivity for mortality to 96.7% (95% CI 82.8% to 99.9%). The agreement between LUS of >=13 and CT score of moderate/severe was 85.7% (95% CI 62.8% to 100%). The interrater agreement between these two parameters was 0.82 (95% CI 0.68, 0.97). Conclusions Multi-organ POCUS is effective in diagnosis, prognosis, and management of COVID-19 patients. Rather than just lung ultrasound, clinicians should use multiorgan POCUS for early identification of severe lung involvement and thrombotic changes;it may help reduce mortality in these patients.