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Potential usefulness of Mediterranean diet polyphenols against COVID-19-induced inflammation: a review of the current knowledge.
Milton-Laskibar, Iñaki; Trepiana, Jenifer; Macarulla, María Teresa; Gómez-Zorita, Saioa; Arellano-García, Laura; Fernández-Quintela, Alfredo; Portillo, María P.
  • Milton-Laskibar I; Precision Nutrition and Cardiometabolic Health Program, IMDEA- Food Institute (Madrid Institute for Advanced Studies), Spanish National Research Council, Campus of International Excellence (CEI) UAM+CSIC, 28049, Madrid, Spain.
  • Trepiana J; CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), 28029, Madrid, Spain.
  • Macarulla MT; CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), 28029, Madrid, Spain.
  • Gómez-Zorita S; Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), Lucio Lascaray Research Center, 01006, Vitoria-Gasteiz, Spain.
  • Arellano-García L; BIOARABA Health Research Institute, 01006, Vitoria-Gasteiz, Spain.
  • Fernández-Quintela A; CIBERobn Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), 28029, Madrid, Spain. mariateresa.macarulla@ehu.eus.
  • Portillo MP; Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy, University of the Basque Country (UPV/EHU), Lucio Lascaray Research Center, 01006, Vitoria-Gasteiz, Spain. mariateresa.macarulla@ehu.eus.
J Physiol Biochem ; 2022 Nov 08.
Article in English | MEDLINE | ID: covidwho-2104137
ABSTRACT
The Mediterranean diet is a dietary pattern typical of the populations living in the Mediterranean basin during the 50s-60s of the last century. This diet has demonstrated beneficial effects in the prevention of several pathologies such as cardiovascular diseases, metabolic syndrome, or several cancer types, at least in part, due to its antioxidant compounds. Since the COVID-19 pandemic started, different authors have been studying the effects of certain dietary habits on the presence of COVID-19 and its severity, and the Mediterranean diet is one of them. This review gathers data from studies supporting the potential usefulness of the main phenolic compounds present in the Mediterranean diet, based on their antioxidant and anti-inflammatory effects, as preventive/therapeutic agents against COVID-19. The current evidence supports the potential benefits that hydroxytyrosol, resveratrol, flavonols such as quercetin, flavanols like catechins, and flavanones on the order of naringenin could have on COVID-19. This is due to the increase in the synthesis and translocations of Nrf-2, which increases the activity of antioxidant enzymes and thus reduces ROS production, the scavenging of free radicals, and the suppression of the activity of MMP-9, which is involved in the cytokine storm, and the inhibition of NF-κB.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Biochemistry / Physiology Year: 2022 Document Type: Article Affiliation country: S13105-022-00926-0

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal subject: Biochemistry / Physiology Year: 2022 Document Type: Article Affiliation country: S13105-022-00926-0