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Is it time for global adoption of endoscopic retrograde appendicitis therapy of acute appendicitis?
Ullah, Saif; Ali, Faisal S; Shi, Miao; Zhang, Ji-Yu; Liu, Bing-Rong.
  • Ullah S; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No. 1 Eastern Jianshe Road, Zhengzhou, Henan 450052, China.
  • Ali FS; Gastroenterology Hepatology and Nutrition Department, University of Texas Health Science Center at Houston, TX, United States.
  • Shi M; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No. 1 Eastern Jianshe Road, Zhengzhou, Henan 450052, China.
  • Zhang JY; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No. 1 Eastern Jianshe Road, Zhengzhou, Henan 450052, China.
  • Liu BR; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No. 1 Eastern Jianshe Road, Zhengzhou, Henan 450052, China; State key Laboratory of Esophageal Cancer Prevention and Treatment, Zhengzhou University, Zhengzhou, China. Electronic address: fccliubr@zzu.edu.cn.
Clin Res Hepatol Gastroenterol ; 46(10): 102049, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2104585
ABSTRACT
Acute appendicitis is a common abdominal surgical emergency worldwide. Abraham Groves performed the first documented open appendectomy in 1883. Although appendectomy is still the most effective treatment in cases of acute appendicitis, it causes a range of complications and carries the risk of negative appendectomy. In the awake of covid-19, the latest guidelines recommend antibiotic therapy as an acceptable first line treatment for acute appendicitis. However, patients treated with antibiotics have a recurrence risk of up to 30% at 1 year. Endoscopic retrograde appendicitis therapy (ERAT) has emerged as promising non-invasive treatment modality for acute uncomplicated appendicitis (AUA) which involves cannulation, appedicography, appendiceal stone extraction, appendiceal lumen irrigation, and stent insertion. ERAT aims to relieve the cause of appendicitis (e.g., obstruction or stenosis of the appendiceal lumen) and thus effectively prevent the recurrence of appendicitis. In addition, it can make a definitive diagnosis of acute appendicitis during endoscopic retrograde appendicography. Studies have shown that 93.8 to 95% of AUA patients did not have a recurrence following ERAT. In this study, we aim to summarize the current body of evidence on ERAT to situate it alongside currently established therapies for acute appendicitis, in particular, AUA.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Appendicitis / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Res Hepatol Gastroenterol Year: 2022 Document Type: Article Affiliation country: J.clinre.2022.102049

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Appendicitis / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: Clin Res Hepatol Gastroenterol Year: 2022 Document Type: Article Affiliation country: J.clinre.2022.102049