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Covid-19 diagnosis and mortality in patients with non-ST-elevation myocardial infarction admitted in Italy during the national outbreak.
De Luca, Leonardo; Rosato, Stefano; D'Errigo, Paola; Giordani, Barbara; Mureddu, Gian Francesco; Badoni, Gabriella; Seccareccia, Fulvia; Baglio, Giovanni.
  • De Luca L; Department of Cardio-Thoracic and Vascular Medicine and Surgery, Division of Cardiology, A.O. San Camillo-Forlanini, Rome, Italy; UniCamillus-Saint Camillus International University of Health Sciences, Rome, Italy. Electronic address: ldeluca@scamilloforlanini.rm.it.
  • Rosato S; National Centre for Global Health, Istituto Superiore di Sanità, Rome, Italy.
  • D'Errigo P; National Centre for Global Health, Istituto Superiore di Sanità, Rome, Italy.
  • Giordani B; Italian National Agency for Regional Healthcare Services, Rome, Italy.
  • Mureddu GF; Division of Cardiology, San Giovanni Addolorata Hospital, Rome, Italy.
  • Badoni G; National Centre for Global Health, Istituto Superiore di Sanità, Rome, Italy.
  • Seccareccia F; National Centre for Global Health, Istituto Superiore di Sanità, Rome, Italy.
  • Baglio G; Italian National Agency for Regional Healthcare Services, Rome, Italy.
Int J Cardiol ; 2022 Nov 07.
Article in English | MEDLINE | ID: covidwho-2240151
ABSTRACT

INTRODUCTION:

We sought to assess the clinical impact of Covid-19 infection on mortality in patients with Non-ST elevation myocardial infarction (NSTEMI) admitted during the national outbreak in Italy.

METHODS:

We analysed a nationwide, comprehensive, and universal administrative database of consecutive NSTEMI patients admitted during lockdown for Covid-19 infection (March,11st - May 3rd, 2020) and the equivalent periods of the previous 5 years in Italy. The observed rate of 30-day and 6-month all-cause mortality of NSTEMI patients with and without Covid-19 infection during the lockdown was compared with the expected rate of death according to the trend of the previous 5 years.

RESULTS:

During the period of observation, 48.447 NSTEMI hospitalizations occurred in Italy. Among these, 4981 NSTEMI patients were admitted during the 2020 outbreak 173 (3.5%) with and 4808 (96.5%) without a Covid-19 diagnosis. According to the 5-year trend, the 2020 expected rate of 30-day and 6-month all-cause mortality was 6.5% and 12.2%, while the observed incidence of death was 8.3% (p = 0.001) and 13.6% (p = 0.041), respectively. Excluding NSTEMI patients with a Covid-19 diagnosis, the 6-month mortality rate resulted in accordance with the prior 5-year trend. After multiple corrections, the presence of Covid-19 diagnosis resulted one of the independent predictors of all-cause mortality at 30 days [adjusted odds ratio (OR) 4.3; 95% confidence intervals (CI) 2.90-6.23; p < 0.0001] and 6 months (adjusted OR 3.5; 95% CI 2.43-5.03; p < 0.0001).

CONCLUSIONS:

During the 2020 national outbreak in Italy, a concomitant diagnosis of Covid-19 in NSTEMI was associated with a significantly higher rate of mortality.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Year: 2022 Document Type: Article