Effect of Inactivated SARS-CoV-2 Vaccines and ChAdOx1 nCoV-19 Vaccination to Prevent COVID-19 in Thai Households (VacPrevent trial)
International Journal of Infectious Diseases
; 124:190-198, 2022.
Article
in English
| Web of Science | ID: covidwho-2105080
ABSTRACT
Objectives:
SARS-CoV-2 is primarily transmitted within households, with massive healthcare system bur-dens. The role of inactivated vaccines and ChAdOx1 nCoV-19 vaccination in the prevention of within -household transmission remains unknown.Methods:
This observational case-control study tracked 408 SARS-CoV-2 polymerase chain reaction- confirmed index cases from April to September 2021. This study aimed to prove the benefit of inactivated and ChAdOx1 nCoV-19 vaccinated index cases in preventing within-household transmissibility.Results:
A total of 1178 household contacts were investigated. A total of 231 index cases were vaccinated with inactivated or ChAdOx1 nCoV-19 vaccine, and 177 were unvaccinated. The vaccinated index cases ex-hibited a 7.8% risk reduction in household transmission. There was no difference in the secondary attack rate of 50.77% in unvaccinated cases compared with 46.81% in vaccinated index cases ( P-value = 0.177). Those who completed the two-dose SARS-CoV-2 vaccination demonstrated a 93% reduction in household transmissibility within 14-90 days. The effectiveness for preventing household transmission was 26.09%. The 87% reduced risk of household transmissibility was observed among those who wore masks.Conclusion:
The completed two-dose SARS-CoV-2 inactivated and ChAdOx1 nCoV-19 vaccination within 14-90 days among index cases demonstrated benefits in preventing within-household transmissibility. Implementing high-efficacy vaccination and an appropriate booster dose can prevent household trans-mission. (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http//creativecommons.org/licenses/by-nc-nd/4.0/ )
Full text:
Available
Collection:
Databases of international organizations
Database:
Web of Science
Type of study:
Experimental Studies
/
Randomized controlled trials
Topics:
Vaccines
Language:
English
Journal:
International Journal of Infectious Diseases
Year:
2022
Document Type:
Article
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