Your browser doesn't support javascript.
A large series of molecular and serological specimens to evaluate mother-to-child SARS-CoV-2 transmission: a prospective study from the Italian Obstetric Surveillance System.
Corsi Decenti, Edoardo; Salvatore, Michele Antonio; Mancon, Alessandro; Portella, Giuseppe; Rocca, Arianna; Vocale, Caterina; Donati, Serena.
  • Corsi Decenti E; Istituto Superiore di Sanità - Italian National Institute of Health, National Centre for Disease Prevention and Health Promotion, 00161 Rome, Italy; University of Rome Tor Vergata, Department of Biomedicine and Prevention, 00133 Rome, Italy.
  • Salvatore MA; Istituto Superiore di Sanità - Italian National Institute of Health, National Centre for Disease Prevention and Health Promotion, 00161 Rome, Italy. Electronic address: micheleantonio.salvatore@iss.it.
  • Mancon A; University Hospital L. Sacco, 20157 Milan, Italy.
  • Portella G; Federico II University of Naples, Dipartimento di Scienze Mediche Traslazionali, 80138 Naples, Italy.
  • Rocca A; Careggi University Hospital, Department of Experimental and Clinical Medicine, 50134 Florence, Italy.
  • Vocale C; Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) - University Hospital of Bologna, Microbiology Unit, 40138 Bologna, Italy.
  • Donati S; Istituto Superiore di Sanità - Italian National Institute of Health, National Centre for Disease Prevention and Health Promotion, 00161 Rome, Italy.
Int J Infect Dis ; 126: 1-9, 2022 Nov 08.
Article in English | MEDLINE | ID: covidwho-2239945
ABSTRACT

OBJECTIVES:

To assay the presence of the SARS-CoV-2 genome in vaginal, rectal, and placental swabs among pregnant women and in newborn nasopharyngeal swabs and to investigate the immunological response and maternal antibody transfer through the umbilical cord blood and milk of unvaccinated mothers.

METHODS:

Vaginal, rectal, and placental specimens, maternal and neonatal serum, and milk were collected from a wide cohort of pregnant Italian women with confirmed SARS-CoV-2 infection admitted to the hospital between February 25, 2020 and June 30, 2021. Samples were tested in selected reference laboratories according to a shared interlaboratory protocol.

RESULTS:

Among 1086 enrolled women, the SARS-CoV-2 positive rate detected in all specimens ranged from 0.7% to 8.4%. Respectively, 45.2% of maternal sera collected during pregnancy and 39.7% of those collected at birth tested positive for immunoglobulin G, whereas 50.5% tested positive among neonates. Nasopharyngeal swabs were positive in 0.8% of the newborns, and immunoglobulin G was detected in 3.0% of the milk samples. The highest immunological response was recorded within 30 days during pregnancy and within 60 days of birth and in the neonatal population.

CONCLUSION:

Vertical transmission should be considered a rare event; although, a good maternal immunological response and antibodies transfer throughout the umbilical cord blood was detected.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2022.10.045

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2022.10.045