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Frequency and burden of neurological manifestations upon hospital presentation in COVID-19 patients: Findings from a large Brazilian cohort.
Marcolino, Milena Soriano; Anschau, Fernando; Kopittke, Luciane; Pires, Magda Carvalho; Barbosa, Izabela Guimarães; Pereira, Daniella Nunes; Ramos, Lucas Emanuel Ferreira; Assunção, Luís Fernando Israel; Costa, André Soares de Moura; Nogueira, Matheus Carvalho Alves; Duani, Helena; Martins, Karina Paula Medeiros Prado; Moreira, Leila Beltrami; Silva, Carla Thais Cândida Alves da; Oliveira, Neimy Ramos de; Ziegelmann, Patricia Klarmann; Guimarães-Júnior, Milton Henriques; Lima, Mauro Oscar Soares de Souza; Aguiar, Rubia Laura Oliveira; Menezes, Luanna Silva Monteiro; Oliveira, Talita Fischer; Souza, Maíra Dias; Farace, Bárbara Lopes; Cimini, Christiane Corrêa Rodrigues; Maurílio, Amanda de Oliveira; Guimarães, Silvana Mangeon Mereilles; Araújo, Silvia Ferreira; Nascimento, Guilherme Fagundes; Silveira, Daniel Vitório; Ruschel, Karen Brasil; Oliveira, Thainara Conceição de; Schwarzbold, Alexandre Vargas; Nasi, Luiz Antônio; Floriani, Maiara Anschau; Santos, Veridiana Baldon Dos; Ramos, Carolina Marques; Alvarenga, Joice Coutinho de; Scotton, Ana Luiza Bahia Alves; Manenti, Euler Roberto Fernandes; Crestani, Gabriela Petry; Batista, Joanna d'Arc Lyra; Ponce, Daniela; Machado-Rugolo, Juliana; Bezerra, Adriana Falangola Benjamin; Martelli, Petrônio José de Lima; Vianna, Heloisa Reniers; Castro, Luís César de; Medeiros, Cássia Regina Gotler; Vietta, Giovanna Grunewald; Pereira, Elayne Crestani.
  • Marcolino MS; Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais. Av. Professor Alfredo Balena 110, Belo Horizonte, Brazil; Telehealth Center, University Hospital, Universidade Federal de Minas Gerais. Av. Professor Alfredo Balena 190, sala 246, Belo Horizonte, Brazil; Institute
  • Anschau F; Grupo Hospitalar Conceição. Brazilian National Health System, Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Av. Francisco Trein, 326, Porto Alegre, Brazil. Electronic address: afernando@ghc.com.br.
  • Kopittke L; Grupo Hospitalar Conceição. Brazilian National Health System, Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Av. Francisco Trein, 326, Porto Alegre, Brazil. Electronic address: kluciane@ghc.com.br.
  • Pires MC; Department of Statistics, Universidade Federal de Minas Gerais. Av. Presidente Antônio Carlos, 6627, ICEx, sala 4071, Belo Horizonte, Brazil. Electronic address: magda@est.ufmg.br.
  • Barbosa IG; Mental Health Department, Medical School, Universidade Federal de Minas Gerais. Av. Professor Alfredo Balena 190, sala 246, Belo Horizonte, Brazil. Electronic address: izabelagb@gmail.com.
  • Pereira DN; Medical School, Universidade Federal de Minas Gerais. Av. Professor Alfredo Balena, 190, Belo Horizonte, Brazil. Electronic address: dani_nunesp@hotmail.com.
  • Ramos LEF; Department of Statistics, Universidade Federal de Minas Gerais. Av. Presidente Antônio Carlos, 6627, ICEx, sala 4071, Belo Horizonte, Brazil. Electronic address: luckermos19@gmail.com.
  • Assunção LFI; Department of Statistics, Universidade Federal de Minas Gerais. Av. Presidente Antônio Carlos, 6627, ICEx, sala 4071, Belo Horizonte, Brazil. Electronic address: assuncaolfi@gmail.com.
  • Costa ASM; Hospitais da Rede Mater Dei. Av. do Contorno, 9000, Belo Horizonte, Brazil. Electronic address: andresmc@gmail.com.
  • Nogueira MCA; Hospitais da Rede Mater Dei. Av. do Contorno, 9000, Belo Horizonte, Brazil. Electronic address: mathnogueira42@gmail.com.
  • Duani H; Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais. Av. Professor Alfredo Balena 110, Belo Horizonte, Brazil. Electronic address: hduani@yahoo.com.br.
  • Martins KPMP; Department of Internal Medicine, Medical School, Universidade Federal de Minas Gerais. Av. Professor Alfredo Balena 110, Belo Horizonte, Brazil. Electronic address: kkpmprado2@gmail.com.
  • Moreira LB; Hospital de Clínicas de Porto Alegre. Av. Protásio Alves, 211, Porto Alegre, Brazil. Electronic address: lbmoreira@hcpa.edu.br.
  • Silva CTCAD; Hospital Santo Antônio. Pç. Dr. Márcio Carvalho Lopes Filho, 501, Curvelo, Brazil. Electronic address: carlatcas@gmail.com.
  • Oliveira NR; Hospital Eduardo de Menezes. R. Dr. Cristiano Rezende, 2213, Belo Horizonte, Brazil. Electronic address: neimyramos@gmail.com.
  • Ziegelmann PK; Hospital Tacchini. R. Dr. José Mário Mônaco, 358, Bento Gonçalves, Brazil. Electronic address: patriciakz99@gmail.com.
  • Guimarães-Júnior MH; Hospital Márcio Cunha. Av. Kiyoshi Tsunawaki, 41, Ipatinga, Brazil. Electronic address: miltonhenriques@yahoo.com.br.
  • Lima MOSS; Hospital Márcio Cunha. Av. Kiyoshi Tsunawaki, 41, Ipatinga, Brazil. Electronic address: mauro.oscar@fsfx.com.br.
  • Aguiar RLO; Hospital Metropolitano Doutor Célio de Castro. R. Dona Luiza, 311, Belo Horizonte, Brazil. Electronic address: rubialaura18@hotmail.com.
  • Menezes LSM; Instituto Mário Penna, Hospital Luxemburgo. R. Joaquim Cândido Filho, 91, Belo Horizonte, Brazil; Hospital Metropolitano Odilon Behrens. R. Formiga, 50, Belo Horizonte, Brazil. Electronic address: luannasmonteiro@gmail.com.
  • Oliveira TF; Hospital Metropolitano Odilon Behrens. R. Formiga, 50, Belo Horizonte, Brazil. Electronic address: talitafischeroliveira@gmail.com.
  • Souza MD; Hospital Metropolitano Odilon Behrens. R. Formiga, 50, Belo Horizonte, Brazil. Electronic address: mairadiassouza@gmail.com.
  • Farace BL; Hospital Risoleta Tolentino Neves. R. das Gabirobas, 01, Belo Horizonte, Brazil. Electronic address: barbarafarace@gmail.com.
  • Cimini CCR; Hospital Santa Rosália. R. Dr. Onófre, 575, Teófilo Otoni, Brazil. Electronic address: christiane.cimini@gmail.com.
  • Maurílio AO; Hospital São João de Deus. R. do Cobre, 800, São João de Deus, Brazil. Electronic address: amandaoliveira.maurilio@gmail.com.
  • Guimarães SMM; Hospital Semper. Alameda Ezequiel Dias, 389, Belo Horizonte, Brazil. Electronic address: smangeon@gmail.com.
  • Araújo SF; Hospital Semper. Alameda Ezequiel Dias, 389, Belo Horizonte, Brazil. Electronic address: silviaferreiragastro@gmail.com.
  • Nascimento GF; Hospital Unimed BH. Av. do Contorno, 3097, Belo Horizonte, Brazil. Electronic address: guilhermefagundesn@hotmail.com.
  • Silveira DV; Hospital Unimed BH. Av. do Contorno, 3097, Belo Horizonte, Brazil. Electronic address: danielvez@gmail.com.
  • Ruschel KB; Institute for Health Technology Assessment (IATS/ CNPq). R. Ramiro Barcelos, 2359, Prédio 21, Sala 507, Porto Alegre, Brazil; Hospital Universitário Canoas. Av. Farroupilha, 8001, Canoas, Rio Grande do Sul, Brazil. Electronic address: karenbruschel@gmail.com.
  • Oliveira TC; Hospital Universitário Canoas. Av. Farroupilha, 8001, Canoas, Rio Grande do Sul, Brazil. Electronic address: thainarastaehler@hotmail.com.
  • Schwarzbold AV; Hospital Universitário de Santa Maria. Av. Roraima, 1000, Santa Maria, Rio Grande do Sul, Brazil. Electronic address: alexvspoa@gmail.com.
  • Nasi LA; Hospital Moinhos de Vento. R. Ramiro Barcelos, 910, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: lnasi@terra.com.br.
  • Floriani MA; Hospital Moinhos de Vento. R. Ramiro Barcelos, 910, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: maiara.floriani@hmv.org.br.
  • Santos VBD; Grupo Hospitalar Conceição. Brazilian National Health System, Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor. Av. Francisco Trein, 326, Porto Alegre, Brazil. Electronic address: veridbaldon@hotmail.com.
  • Ramos CM; Hospital Julia Kubitschek. Av. Professor Alfredo Balena, 190, Belo Horizonte, Brazil. Electronic address: carol.marques@live.com.
  • Alvarenga JC; Hospital João XXIII. Av. Professor Alfredo Balena, 400, Belo Horizonte, Brazil. Electronic address: joice-alvarenga@hotmail.com.
  • Scotton ALBA; Hospital Regional Antônio Dias. R. Maj. Gote, 1231, Patos de Minas, Brazil. Electronic address: analuiza.bahia@yahoo.com.br.
  • Manenti ERF; Hospital Mãe de Deus. R. José de Alencar, 286, Porto Alegre, Brazil. Electronic address: eulermanenti@gmail.com.
  • Crestani GP; Hospital Mãe de Deus. R. José de Alencar, 286, Porto Alegre, Brazil. Electronic address: gabrielapetryc@gmail.com.
  • Batista JDL; Universidade Federal Fronteira do Sul. Av. Fernando Machado, 108E, Santa Catarina, Brazil. Electronic address: joannalyra@gmail.com.
  • Ponce D; Hospital das Clínicas da Faculdade de Medicina de Botucatu. Av. Professor Mário Rubens Guimarães Montenegro, Botucatu, São Paulo, Brazil. Electronic address: daniela.ponce@unesp.br.
  • Machado-Rugolo J; Hospital das Clínicas da Faculdade de Medicina de Botucatu. Av. Professor Mário Rubens Guimarães Montenegro, Botucatu, São Paulo, Brazil. Electronic address: jr.machado@unesp.br.
  • Bezerra AFB; Hospital das Clínicas da Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235, Pernambuco, Brazil. Electronic address: adriana.bbezerra@ufpe.br.
  • Martelli PJL; Hospital das Clínicas da Universidade Federal de Pernambuco. Av. Prof. Moraes Rego, 1235, Pernambuco, Brazil. Electronic address: petroniocarla@uol.com.br.
  • Vianna HR; Hospital Universitário Ciências Médicas. R. dos Aimorés, 2896, Belo Horizonte, Brazil. Electronic address: hrvianna@hotmail.com.
  • Castro LC; Hospital Bruno Born. Av. Benjamin Constant, 881, Lajeado, Brazil. Electronic address: pharmlucamsc@gmail.com.
  • Medeiros CRG; Hospital Bruno Born. Av. Benjamin Constant, 881, Lajeado, Brazil. Electronic address: enfmedeiros@univates.br.
  • Vietta GG; Hospital SOS Cárdio. Rod. SC-401, 121, Florianópolis, Brazil. Electronic address: ggvietta@gmail.com.
  • Pereira EC; Hospital SOS Cárdio. Rod. SC-401, 121, Florianópolis, Brazil. Electronic address: elaynepp@yahoo.com.br.
J Neurol Sci ; 443: 120485, 2022 Dec 15.
Article in English | MEDLINE | ID: covidwho-2105434
ABSTRACT

BACKGROUND:

Scientific data regarding the prevalence of COVID-19 neurological manifestations and prognosis in Latin America countries is still lacking. Therefore, the study aims to understand neurological manifestations of SARS-CoV 2 infection and outcomes in the Brazilian population.

METHODS:

This study is part of the Brazilian COVID-19 Registry, a multicentric cohort, including data from 37 hospitals. For the present analysis, patients were grouped according to the presence of reported symptoms (i.e., headache; anosmia and ageusia; syncope and dizziness) vs. clinically-diagnosed neurological manifestations (clinically-defined neurological syndrome neurological signs or diagnoses captured by clinical evaluation) and matched with patients without neurological manifestations by age, sex, number of comorbidities, hospital of admission, and whether or not patients had underlying neurological disease.

RESULTS:

From 6,635 hospitalized patients with COVID-19, 30.8% presented reported neurological manifestations, 10.3% were diagnosed with a neurological syndrome and 60.1% did not show any neurological manifestations. In patients with reported symptoms, the most common ones were headache (20.7%), ageusia (11.1%) and anosmia (8.0%). In patients with neurological syndromes, acute encephalopathy was the most common diagnosis (9.7%). In the matched analysis, patients with neurological syndromes presented more cases of septic shock (17.0 vs. 13.0%, p = 0.045), intensive care unit admission (45.3 vs. 38.9%, p = 0.023), and mortality (38.7 vs. 32.6%, p = 0.026; and 39.2 vs. 30.3%, p < 0.001) when compared to controls.

CONCLUSION:

COVID-19 in-hospital patients with clinically defined neurological syndromes presented a higher incidence of septic shock, ICU admission and death when compared to controls.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Shock, Septic / Ageusia / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: J Neurol Sci Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Shock, Septic / Ageusia / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Country/Region as subject: South America / Brazil Language: English Journal: J Neurol Sci Year: 2022 Document Type: Article