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Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study.
Etter, Manina M; Martins, Tomás A; Kulsvehagen, Laila; Pössnecker, Elisabeth; Duchemin, Wandrille; Hogan, Sabrina; Sanabria-Diaz, Gretel; Müller, Jannis; Chiappini, Alessio; Rychen, Jonathan; Eberhard, Noëmi; Guzman, Raphael; Mariani, Luigi; Melie-Garcia, Lester; Keller, Emanuela; Jelcic, Ilijas; Pargger, Hans; Siegemund, Martin; Kuhle, Jens; Oechtering, Johanna; Eich, Caroline; Tzankov, Alexandar; Matter, Matthias S; Uzun, Sarp; Yaldizli, Özgür; Lieb, Johanna M; Psychogios, Marios-Nikos; Leuzinger, Karoline; Hirsch, Hans H; Granziera, Cristina; Pröbstel, Anne-Katrin; Hutter, Gregor.
  • Etter MM; Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Martins TA; Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Kulsvehagen L; Departments of Neurology, Biomedicine and Clinical Research, & Research Center for Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Pössnecker E; Departments of Neurology, Biomedicine and Clinical Research, & Research Center for Neuroimmunology and Neuroscience Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Duchemin W; sciCORE Center for Scientific Computing, University of Basel, Basel, Switzerland.
  • Hogan S; Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Sanabria-Diaz G; Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Müller J; Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Chiappini A; Department of Neurology, University Hospital Basel, Basel, Switzerland.
  • Rychen J; Department of Neurosurgery, University Hospital Basel, Basel, Switzerland.
  • Eberhard N; Department of Neurosurgery, University Hospital Basel, Basel, Switzerland.
  • Guzman R; Department of Neurosurgery, University Hospital Basel, Basel, Switzerland.
  • Mariani L; Department of Neurosurgery, University Hospital Basel, Basel, Switzerland.
  • Melie-Garcia L; Department of Surgery, University Hospital Basel, Spitalstrasse 21, Basel, Switzerland.
  • Keller E; Department of Neurosurgery, University Hospital Basel, Basel, Switzerland.
  • Jelcic I; Department of Surgery, University Hospital Basel, Spitalstrasse 21, Basel, Switzerland.
  • Pargger H; Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Siegemund M; Department of Neurology, University Hospital Basel, Basel, Switzerland.
  • Kuhle J; Neurosurgical Intensive Care Unit, Department of Neurosurgery and Institute of Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland.
  • Oechtering J; Neuroimmunology and Multiple Sclerosis Research Section, Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
  • Eich C; Department of Intensive Care Medicine, University Hospital Basel, Basel, Switzerland.
  • Tzankov A; Department of Intensive Care Medicine, University Hospital Basel, Basel, Switzerland.
  • Matter MS; Department of Neurology, University Hospital Basel, Basel, Switzerland.
  • Uzun S; Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Yaldizli Ö; Department of Neurology, University Hospital Basel, Basel, Switzerland.
  • Lieb JM; Brain Tumor Immunotherapy Lab, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Psychogios MN; Department of Pathology, Institute of Medical Genetics & Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Leuzinger K; Department of Pathology, Institute of Medical Genetics & Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Hirsch HH; Department of Pathology, Institute of Medical Genetics & Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Granziera C; Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Pröbstel AK; Department of Neuroradiology, Clinic for Radiology & Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
  • Hutter G; Department of Neuroradiology, Clinic for Radiology & Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Nat Commun ; 13(1): 6777, 2022 11 09.
Article in English | MEDLINE | ID: covidwho-2106404
ABSTRACT
Growing evidence links COVID-19 with acute and long-term neurological dysfunction. However, the pathophysiological mechanisms resulting in central nervous system involvement remain unclear, posing both diagnostic and therapeutic challenges. Here we show outcomes of a cross-sectional clinical study (NCT04472013) including clinical and imaging data and corresponding multidimensional characterization of immune mediators in the cerebrospinal fluid (CSF) and plasma of patients belonging to different Neuro-COVID severity classes. The most prominent signs of severe Neuro-COVID are blood-brain barrier (BBB) impairment, elevated microglia activation markers and a polyclonal B cell response targeting self-antigens and non-self-antigens. COVID-19 patients show decreased regional brain volumes associating with specific CSF parameters, however, COVID-19 patients characterized by plasma cytokine storm are presenting with a non-inflammatory CSF profile. Post-acute COVID-19 syndrome strongly associates with a distinctive set of CSF and plasma mediators. Collectively, we identify several potentially actionable targets to prevent or intervene with the neurological consequences of SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-34068-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-34068-0