Risk of glomerular diseases, proteinuria and hematuria following mRNA (BNT162b2) and inactivated (CoronaVac) SARS-CoV-2 vaccines.
Nephrol Dial Transplant
; 2022 Oct 28.
Article
in English
| MEDLINE | ID: covidwho-2293315
ABSTRACT
BACKGROUND:
With accruing case reports on de novo or relapsing glomerular diseases (GD) following different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines, we evaluated the risk of GD following BNT162b2 and CoronaVac vaccines.METHODS:
A modified self-controlled case series analysis was conducted using anonymized, territory-wide SARS-CoV-2 vaccination records in Hong Kong. All Hong Kong residents aged 18 years or above with outcomes of interest were included. Outcomes of interest were GD, proteinuria or hematuria within 42 days following each dose of SARS-CoV-2 vaccines. Incidence per 100 000 doses of SARS-CoV-2 vaccines administered was calculated, and incidence rate ratios (IRRs) were estimated using conditional Poisson regression with seasonality adjustment.RESULTS:
Between 23 February 2021 and 31 March 2022, 4062 patients had an incident diagnosis of GD, proteinuria or hematuria, with 2873 of them being vaccinated during the observation period. The incidences of the composite events 1-41 days after vaccination were 3.7 (95% CI 3.1-4.4) per 100 000 doses of BNT162b2 administered, and 6.5 (95% CI 5.7-7.5) per 100 000 doses CoronaVac administered. There was no significant increase in the risks of composite events following the first (BNT162b2 IRR = 0.76, 95% CI 0.56-1.03; CoronaVac IRR = 0.92, 95% CI 0.72-1.19), second (BNT162b2 IRR = 0.92, 95% CI 0.72-1.17; CoronaVac IRR = 0.88. 95% CI 0.68-1.14) or third (BNT162b2 IRR = 0.39. 95% CI 0.15-1.03; CoronaVac IRR = 1.18. 95% CI 0.53-2.63) dose of SARS-CoV-2 vaccines.CONCLUSIONS:
There was no evidence of increased risks of de novo or relapsing GD with either BNT162b2 or CoronaVac vaccines.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Language:
English
Journal subject:
Nephrology
/
Transplantation
Year:
2022
Document Type:
Article
Affiliation country:
Ndt
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