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High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone.
Butcher, Lee; Zaldua, Jun-Cezar; Carnicero, Jose A; Hawkins, Karl; Whitley, Janet; Mothukuri, Rangaswamy; Evans, Phillip A; Morris, Keith; Pillai, Suresh; Erusalimsky, Jorge D.
  • Butcher L; The Cellular Senescence and Pathophysiology Group, Cardiff Metropolitan University, Llandaff Campus, Western Avenue, Cardiff, CF5 2YB, UK.
  • Zaldua JC; Welsh Centre for Emergency Medicine Research, Emergency Department, Morriston Hospital, Swansea Bay University Health Board, Swansea, SA6 6NL, UK.
  • Carnicero JA; Fundación para la Investigación Biomédica del Hospital Universitario de Getafe, Getafe, Spain.
  • Hawkins K; Medical School, Swansea University, Swansea, UK.
  • Whitley J; Welsh Centre for Emergency Medicine Research, Emergency Department, Morriston Hospital, Swansea Bay University Health Board, Swansea, SA6 6NL, UK.
  • Mothukuri R; Welsh Centre for Emergency Medicine Research, Emergency Department, Morriston Hospital, Swansea Bay University Health Board, Swansea, SA6 6NL, UK.
  • Evans PA; Welsh Centre for Emergency Medicine Research, Emergency Department, Morriston Hospital, Swansea Bay University Health Board, Swansea, SA6 6NL, UK.
  • Morris K; The Cellular Senescence and Pathophysiology Group, Cardiff Metropolitan University, Llandaff Campus, Western Avenue, Cardiff, CF5 2YB, UK.
  • Pillai S; Welsh Centre for Emergency Medicine Research, Emergency Department, Morriston Hospital, Swansea Bay University Health Board, Swansea, SA6 6NL, UK. SureshKumar.GopalaPillai@wales.nhs.uk.
  • Erusalimsky JD; The Cellular Senescence and Pathophysiology Group, Cardiff Metropolitan University, Llandaff Campus, Western Avenue, Cardiff, CF5 2YB, UK. jderusalimsky@cardiffmet.ac.uk.
Respir Res ; 23(1): 303, 2022 Nov 05.
Article in English | MEDLINE | ID: covidwho-2108781
ABSTRACT
Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19. However, the prognostic performance of this biomarker in the context of treatments to reduce inflammation is unclear. In this study we investigated the association between sRAGE and mortality in dexamethasone-treated COVID-19 patients. We studied 89 SARS-CoV-2 positive subjects and 22 controls attending the emergency department of a University Teaching Hospital during the second wave of COVID-19 and measured sRAGE at admission. In positive individuals sRAGE increased with disease severity and correlated with the National Early Warning Score 2 (Pearson's r = 0.56, p < 0.001). Fourteen out of 72 patients treated with dexamethasone died during 28 days of follow-up. Survival rates were significantly lower in patients with high sRAGE (> 3532 pg/mL) than in those with low sRAGE (p = 0.01). Higher sRAGE levels were associated with an increased risk of death after adjustment for relevant covariates. In contrast, IL-6 did not predict mortality in these patients. These results demonstrate that sRAGE remains an independent predictor of mortality among COVID-19 patients treated with dexamethasone. Determination of sRAGE could be useful for the clinical management of this patient population.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment Type of study: Cohort study / Prognostic study Limits: Humans Language: English Journal: Respir Res Year: 2022 Document Type: Article Affiliation country: S12931-022-02220-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment Type of study: Cohort study / Prognostic study Limits: Humans Language: English Journal: Respir Res Year: 2022 Document Type: Article Affiliation country: S12931-022-02220-5