Preadmission Use Of Antidiabetic Medications And Mortality Among Patients With Covid-19 Having Type 2 Diabetes: A Meta-analysis
J Endocr Soc
; 6(Suppl 1):A345, 2022.
Article
in English
| PubMed Central | ID: covidwho-2109238
ABSTRACT
Introduction:
Diabetes is an independent predictor of poor outcomes in patients with COVID-19. We compared the effects of the preadmission use of antidiabetic medications on the in-hospital mortality of patients with COVID-19 having type 2 diabetes.Methods:
A systematic search was performed until November 30, 2021. We used a random-effects meta-analysis to calculate the pooled OR (95% CI).Results:
We included 61 studies (3,061,584 individuals). We found some medications protective against COVID-related death, including metformin, GLP-1RA and SGLT-2i. DPP-4i and insulin users were more likely to die during hospitalization. SU, TZD, and AGI were mortality neutral. Metformin use was associated with better outcome in a dose-response manner.Conclusions:
Metformin, GLP-1RA, and SGLT-2i were associated with lower mortality rate in patients with COVID-19 having type 2 diabetes. DPP-4i and insulin were linked to increased mortality. SU, TZD and AGI were mortality neutral.Presentation No date and time listed
Full text:
Available
Collection:
Databases of international organizations
Database:
PubMed Central
Type of study:
Reviews
Language:
English
Journal:
J Endocr Soc
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS