Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies.
Viruses
; 14(10)2022 10 06.
Article
in English
| MEDLINE | ID: covidwho-2110268
ABSTRACT
RNA-dependent RNA polymerases (RdRPs) represent a distinctive yet versatile class of nucleic acid polymerases encoded by RNA viruses for the replication and transcription of their genome. The structure of the RdRP is comparable to that of a cupped right hand consisting of fingers, palm, and thumb subdomains. Despite the presence of a common structural core, the RdRPs differ significantly in the mechanistic details of RNA binding and polymerization. The present review aims at exploring these incongruities in light of recent structural studies of RdRP complexes with diverse cofactors, RNA moieties, analogs, and inhibitors.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA Viruses
/
Nucleic Acids
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
V14102200
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