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Do We Really Need Omicron Spike-Based Updated COVID-19 Vaccines? Evidence and Pipeline.
Focosi, Daniele; Maggi, Fabrizio.
  • Focosi D; North-Western Tuscany Blood Bank, Pisa University Hospital, 56124 Pisa, Italy.
  • Maggi F; National Institute for Infectious Diseases "L. Spallanzani", 00161 Roma, Italy.
Viruses ; 14(11)2022 Nov 10.
Article in English | MEDLINE | ID: covidwho-2110273
ABSTRACT
The wild-type SARS-CoV-2 Spike-based vaccines authorized so far have reduced COVID-19 severity, but periodic boosts are required to counteract the decline in immunity. An accelerated rate of immune escape to vaccine-elicited immunity has been associated with Spike protein antigenic shifts, as seen in the Omicron variant of concern and its sublineages, demanding the development of Omicron Spike-based vaccines. Herein, we review the evidence in animal models and topline results from ongoing clinical trials with such updated vaccines, discussing the pros and cons for their deployment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14112488

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14112488