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Hesitancy toward the Full COVID-19 Vaccination among Kidney, Liver and Lung Transplant Recipients in Italy.
Costantino, Andrea; Morlacchi, Letizia; Donato, Maria Francesca; Gramegna, Andrea; Farina, Elisa; Dibenedetto, Clara; Campise, Mariarosaria; Redaelli, Matteo; Perego, Marta; Alfieri, Carlo; Blasi, Francesco; Lampertico, Pietro; Favi, Evaldo.
  • Costantino A; Division of Gastroenterology and Endoscopy, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20214 Milan, Italy.
  • Morlacchi L; Department of Pathophysiology and Transplantation, Università Degli Studi di Milano, 20124 Milan, Italy.
  • Donato MF; Respiratory Unit and Adult Cystic Fibrosis Center, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.
  • Gramegna A; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
  • Farina E; Department of Pathophysiology and Transplantation, Università Degli Studi di Milano, 20124 Milan, Italy.
  • Dibenedetto C; Respiratory Unit and Adult Cystic Fibrosis Center, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.
  • Campise M; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
  • Redaelli M; Division of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
  • Perego M; Nephrology Dialysis and Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.
  • Alfieri C; Kidney Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.
  • Blasi F; Kidney Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.
  • Lampertico P; Nephrology Dialysis and Transplantation, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20124 Milan, Italy.
  • Favi E; Department of Clinical Sciences and Community Health, Università Degli Studi di Milano, 20124 Milan, Italy.
Vaccines (Basel) ; 10(11)2022 Nov 10.
Article in English | MEDLINE | ID: covidwho-2110297
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) vaccination hesitancy is a threat as COVID-19 vaccines have reduced both viral transmission and virus-associated mortality rates, particularly in high-risk subgroups. Solid organ transplant recipients (SOTRs) are particularly vulnerable, as the underlying causes of their organ failure and the chronic immunosuppression are associated with a lower immune response to COVID-19 vaccines, and with an excessive risk of death due to SARS-CoV-2 infection. We aimed to evaluate COVID-19 vaccination hesitancy and its reasons in a population of SOTRs.

METHODS:

All the SOTRs attending our post-transplant clinics were asked to fill in a vaccination status form with specific validated questions related to their willingness to receive a third vaccine dose. In the case of negative answers, the patients were encouraged to explain the reasons for their refusal. Among the SOTRs (1899), 1019 were investigated (53.7%).

RESULTS:

Overall, 5.01% (51/1019) of the SOTRs raised concerns regarding the future third dose vaccination. In more detail, hesitancy rates were 3.3% (15/453), 4.2% (7/166), and 7.3% (29/400) among the investigated liver, lung, and kidney transplant recipients, respectively (p = 0.0018). The main reasons for hesitancy were fear of adverse events (30/51, 58.8%) and perceived lack of efficacy (21/51, 41.2%).

CONCLUSIONS:

Full adherence to ongoing or future vaccination campaigns is crucial to prevent, or at least reduce, COVID-19-related morbidity and mortality in fragile patients. The identification of the reasons influencing COVID-19 vaccination hesitancy in these patients is very important to establish appropriate and targeted patient-doctor communication strategies, and to further implement specific vaccination campaigns.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10111899

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10111899