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Increased COVID-19 mortality in patients with rheumatic diseases: results from the CONTROL-19 study by the Italian Society for Rheumatology.
Zanetti, Anna; Carrara, Greta; Landolfi, Gianpiero; Rozza, Davide; Chighizola, Cecilia Beatrice; Alunno, Alessia; Andreoli, Laura; Caporali, Roberto; Gerli, Roberto; Sebastiani, Gian Domenico; Valesini, Guido; Sinigaglia, Luigi; Raffeiner, Bernd; Lomater, Claudia; Caprioli, Marta; Fredi, Micaela; Romeo, Nicoletta; Cuomo, Giovanna; Vadacca, Marta; Scirè, Carlo Alberto.
  • Zanetti A; Epidemiology Research Unit, Italian Society for Rheumatology, Milan, and Department of Statistics and Quantitative Methods, Division of Biostatistics, Epidemiology and Public Health, University of Milano-Bicocca, Milan, Italy.
  • Carrara G; Epidemiology Research Unit, Italian Society for Rheumatology, Milan, Italy.
  • Landolfi G; Epidemiology Research Unit, Italian Society for Rheumatology, Milan, Italy.
  • Rozza D; Epidemiology Research Unit, Italian Society for Rheumatology, Milan, Italy.
  • Chighizola CB; Department of Clinical Sciences and Community Health, Research Center for Adult and Paediatric Rheumatic Diseases, University of Milan, Paediatric Rheumatology Unit, ASST G. Pini and CTO, Milan, Italy.
  • Alunno A; Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
  • Andreoli L; Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, Brescia, and Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Caporali R; Department of Clinical Sciences and Community Health, University of Milan, ASST Pini CTO, Milan, Italy.
  • Gerli R; Rheumatology Unit, Department of Medicine, University of Perugia, Italy.
  • Sebastiani GD; Rheumatology Unit, Azienda Ospedaliera San Camillo-Forlanini, Roma, Italy.
  • Valesini G; Rheumatology, Department of Internal Medicine and Medical Specialities, Sapienza University of Rome, Italy.
  • Sinigaglia L; Past President of the Italian Society for Rheumatology, Italy.
  • Raffeiner B; Department of Rheumatology, Central Hospital of Bolzano, Italy.
  • Lomater C; Rheumatology Unit, Mauriziano Hospital, Turin, Italy.
  • Caprioli M; Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center - IRCCS, Rozzano, Milan, Italy.
  • Fredi M; Rheumatology and Clinical Immunology Unit, ASST Spedali Civili, Brescia, and Department of Clinical and Experimental Sciences, University of Brescia, Italy.
  • Romeo N; Azienda Sanitaria Ospedialiero S. Croce e Carle, Cuneo, Italy.
  • Cuomo G; Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Vadacca M; Rheumatology and Immunology Unit, Department of Medicine, University of Rome Campus Bio-Medico, Rome, Italy.
  • Scirè CA; Epidemiology Research Unit, Italian Society for Rheumatology, Milan, and Rheumatology Unit, Department of Medical Sciences, University of Ferrara, Italy. c.scire@reumatologia.it.
Clin Exp Rheumatol ; 40(11): 2038-2043, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-2111743
ABSTRACT

OBJECTIVES:

To investigate differences in coronavirus disease 2019 (COVID-19) mortality between patients with rheumatic musculoskeletal diseases (RMD) and the general population in Italy.

METHODS:

We analysed the data from the national surveillance study promoted by the Italian Society for Rheumatology (CONTROL-19 database) including patients with RMD and COVID-19 between 26 March 2020 and 29 November 2020, compared with official data from the Italian population (within the same period) adjusted for age, sex and geographic location. The main outcome of the analyses was mortality. The relationship between RMD and mortality was analysed using adjusted logistic models and sensitivity analyses were conducted to support the robustness of our results.

RESULTS:

We included 668 RMD patients (62.7% with inflammatory arthritis, 28.6% with systemic autoimmune diseases), who had a mean age of 58.4 years and of which 66% were female. Compared to the general population, the RMD population showed an increased risk of death (OR 3.10 (95% CI 2.29-4.12)), independently from the differences in age and sex distribution. Even after considering the potential influence of surveillance bias, the OR was 2.08 (95% CI 1.55-2.73). Such excess of risk was more evident in the subgroup of younger patients, and more consistent in women. Subjects with systemic autoimmune diseases showed a higher risk of death than patients with any other RMDs.

CONCLUSIONS:

Patients with RMD and COVID-19 infection evidenced a significant increase in mortality during the first pandemic phases in Italy. These findings support the need for strong SARS-CoV-2 prevention in patients with rheumatic diseases.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Rheumatology / Autoimmune Diseases / Rheumatic Diseases / Musculoskeletal Diseases / COVID-19 Type of study: Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Language: English Journal: Clin Exp Rheumatol Year: 2022 Document Type: Article Affiliation country: Clinexprheumatol

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Rheumatology / Autoimmune Diseases / Rheumatic Diseases / Musculoskeletal Diseases / COVID-19 Type of study: Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Language: English Journal: Clin Exp Rheumatol Year: 2022 Document Type: Article Affiliation country: Clinexprheumatol