Comparison of Abbott CMIA and EUROIMMUN ELISA Anti-SARS-CoV-2 IgG Results
Eesti Arst
; 101(Supplement 4):37, 2022.
Article
in English
| EMBASE | ID: covidwho-2111915
ABSTRACT
Objectives. A variety of different anti-SARS-CoV-2 IgG antibody tests are already available in medical laboratories worldwide, and it is quite difficult to compare obtained results due to the diversity and lack of standardization. METHODS. The study included 16 serum samples of patients vaccinated against COVID-19 with different kinds of vaccines and their combinations. Two commonly used anti-SARS-CoV-2 IgG spike protein antibody quantitative assays (Abbott Chemiluminescent Microparticle Immunoassay (CMIA) and EUROIMMUN ELISA) were evaluated for correlation. RESULTS. SARS-CoV-2 IgG antibody results of Abbott CMIA and EUROIMMUN ELISA assays demonstrated a good correlation (r = 0.7902) between obtained results among patients. Only one sample showed discordant results, respectively;CMIA displayed positive (68 AU/mL;cut-off value is 50 AU/mL), but ELISA-a negative (0.7 ratio;cut-off value is 0.8 ratio) result. CONCLUSIONS. Anti-SARS-Cov-2 IgG spike protein antibody results correlate between Abbott CMIA and EUROIMMUN ELISA assay, despite the lack of standardization of these assays. However, more studies with a wider range of participants need to be carried out to fully demonstrate and prove this correlation, also considering each patient's history of vaccination against COVID-19 and possible COVID-19 infection in their medical history.
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Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Eesti Arst
Year:
2022
Document Type:
Article
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